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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ppardtm1Dgen
targeted mutation 1, Deltagen
MGI:3604590
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ppardtm1Dgen/Ppardtm1Dgen involves: 129P2/OlaHsd * C57BL/6 MGI:3606647
ht2
 		Ppardtm1Dgen/Ppard+ involves: 129P2/OlaHsd * C57BL/6 MGI:3606648


Genotype
MGI:3606647
hm1
Allelic
Composition		 Ppardtm1Dgen/Ppardtm1Dgen
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppardtm1Dgen mutation (1 available); any Ppard mutation (68 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, incomplete penetrance ( J:101679 )
• most homozygous embryos die between E8.5 and E10.5

nervous system
dilated lateral ventricle ( J:101679 )
• moderate dilation of both ventricles of the cerebrum is seen in surviving homozygous females at 49 days of age




Genotype
MGI:3606648
ht2
Allelic
Composition		 Ppardtm1Dgen/Ppard+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppardtm1Dgen mutation (1 available); any Ppard mutation (68 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
decreased thermal nociceptive threshold ( J:101679 )
• mean latency is decreased in the hot plate test




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory