Phenotypes associated with this allele

• Allele Symbol: Grm1^tm1Dgen
• Allele Name: targeted mutation 1, Deltagen
• Allele ID: MGI:3604591
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grm1^tm1Dgen/Grm1^tm1Dgen	involves: 129P2/OlaHsd * C57BL/6	MGI:3606471

Genotype
MGI:3606471

hm1

• Allelic Composition: Grm1^tm1Dgen/Grm1^tm1Dgen
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:101679 )

• homozygotes die before 90 days of age

behavior/neurological

ataxia ( J:101679 )

• seen at 20 and 49 days of age

impaired limb coordination ( J:101679 )

• at 20 days of age stumbling and paddling movements are seen and at 49 days of age homozygotes are uncoordinated

weakness ( J:101679 )

• seen at 49 days of age

hunched posture ( J:101679 )

• seen at 20 and 49 days of age

decreased locomotor activity ( J:101679 )

• een at 20 days of age

growth/size/body

decreased body size ( J:101679 )

• homozygotes are thin at 20 days of age and runted and thin at 49 days of age

decreased body weight ( J:101679 )

• seen at 49 days of age

skeleton

decreased bone mineral content ( J:101679 )

• bone mineral content is reduced in female homozygotes

decreased bone mineral density ( J:101679 )

• bone mineral density is reduced in female homozygotes