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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kcnq2tm1Dgen
targeted mutation 1, Deltagen
MGI:3604594
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Kcnq2tm1Dgen/Kcnq2tm1Dgen B6.129P2-Kcnq2tm1Dgen/J MGI:3830651
hm2
 		Kcnq2tm1Dgen/Kcnq2tm1Dgen involves: 129P2/OlaHsd * C57BL/6 MGI:3606652
ht3
 		Kcnq2tm1Dgen/Kcnq2+ B6.129P2-Kcnq2tm1Dgen/J MGI:4818911
ht4
 		Kcnq2tm1Dgen/Kcnq2+ involves: 129P2/OlaHsd * C57BL/6 MGI:3606653


Genotype
MGI:3830651
hm1
Allelic
Composition		 Kcnq2tm1Dgen/Kcnq2tm1Dgen
Genetic
Background		 B6.129P2-Kcnq2tm1Dgen/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnq2tm1Dgen mutation (1 available); any Kcnq2 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal afterhyperpolarization ( J:142688 )
• the peak amplitude of apamin-insensitivie medium afterhyperpolarization current of dentate gyrus granule cells is decreased compared to in wild-type mice
• however, apamin-insensitive medium afterhyperpolarization currents in CA1 pyramidal cells are normal
• apamin-insensitive slow afterhyperpolarization current of dentate gyrus granule cells is reduced 50% compared to in wild-type cells




Genotype
MGI:3606652
hm2
Allelic
Composition		 Kcnq2tm1Dgen/Kcnq2tm1Dgen
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnq2tm1Dgen mutation (1 available); any Kcnq2 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, incomplete penetrance ( J:101679 )
• homozygotes frequently are not found at weaning




Genotype
MGI:4818911
ht3
Allelic
Composition		 Kcnq2tm1Dgen/Kcnq2+
Genetic
Background		 B6.129P2-Kcnq2tm1Dgen/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnq2tm1Dgen mutation (1 available); any Kcnq2 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased prepulse inhibition ( J:161844 )
• at the 78, 86, and 90 dB prepulse levels
• however, in the absence of a prepulse acoustic startle responses are normal




Genotype
MGI:3606653
ht4
Allelic
Composition		 Kcnq2tm1Dgen/Kcnq2+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnq2tm1Dgen mutation (1 available); any Kcnq2 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
increased susceptibility to pharmacologically induced seizures ( J:101679 )
• heterozygotes require a lower dose of metrazol to induce various seizure stages compared to wild-type mice

nervous system
increased susceptibility to pharmacologically induced seizures ( J:101679 )
• heterozygotes require a lower dose of metrazol to induce various seizure stages compared to wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory