Phenotypes associated with this allele

• Allele Symbol: Ppm1f^tm1Dgen
• Allele Name: targeted mutation 1, Deltagen
• Allele ID: MGI:3604597
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ppm1f^tm1Dgen/Ppm1f^tm1Dgen	involves: 129P2/OlaHsd * C57BL/6	MGI:3606444
ht2	Ppm1f^tm1Dgen/Ppm1f^+	involves: 129P2/OlaHsd * C57BL/6	MGI:3606446

Genotype
MGI:3606444

hm1

• Allelic Composition: Ppm1f^tm1Dgen/Ppm1f^tm1Dgen
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:101679 )

• no homozygous mice identified at weaning and the genotypic ratio suggests either embryonic or perinatal lethality

Genotype
MGI:3606446

ht2

• Allelic Composition: Ppm1f^tm1Dgen/Ppm1f⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

behavior/neurological

increased locomotor activity ( J:101679 )

• exhibit an increase in total distance traveled during open field testing, indicating possible hyperactivity

increased thermal nociceptive threshold ( J:101679 )

• significant increase in latency to lick a hindpaw or jump during hot plate testing, indicating a possible increase in pain threshold