Phenotypes associated with this allele

• Allele Symbol: Hcrtr1^tm1Dgen
• Allele Name: targeted mutation 1, Deltagen
• Allele ID: MGI:3604598
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hcrtr1^tm1Dgen/Hcrtr1^tm1Dgen	B6.129P2-Hcrtr1^tm1Dgen/J	MGI:5610038
hm2	Hcrtr1^tm1Dgen/Hcrtr1^tm1Dgen	involves: 129P2/OlaHsd * C57BL/6	MGI:3606521

Genotype
MGI:5610038

hm1

• Allelic Composition: Hcrtr1^tm1Dgen/Hcrtr1^tm1Dgen
• Genetic Background: B6.129P2-Hcrtr1^tm1Dgen/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal cocaine consumption ( J:208627 , J:216923 )

• significantly lower cocaine self administration (J:208627)

• treatment with SB334867 partially restores cocaine self-administration (J:208627)

• significantly lower cocaine self administration across a broad range of doses (J:216923)

• however, response to food rewards is similar to wild-type controls (J:216923)

low preference for an addictive substance ( J:208627 , J:216923 )

• significantly lower cocaine self administration (J:208627)

• treatment with SB334867 partially restores cocaine self-administration (J:208627)

• significantly lower cocaine self administration across a broad range of doses (J:216923)

• however, response to food rewards is similar to wild-type controls (J:216923)

Genotype
MGI:3606521

hm2

• Allelic Composition: Hcrtr1^tm1Dgen/Hcrtr1^tm1Dgen
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

behavior/neurological

increased susceptibility to pharmacologically induced seizures ( J:101679 )

• homozygotes require a lower dose of metrazol to induce various seizure stages compared to wild-type mice

nervous system

increased susceptibility to pharmacologically induced seizures ( J:101679 )

• homozygotes require a lower dose of metrazol to induce various seizure stages compared to wild-type mice