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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lats2tm1Dgen
targeted mutation 1, Deltagen
MGI:3604602
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lats2tm1Dgen/Lats2tm1Dgen involves: 129P2/OlaHsd * C57BL/6 MGI:3606567
ht2
 		Lats2tm1Dgen/Lats2+ involves: 129P2/OlaHsd * C57BL/6 MGI:3606568


Genotype
MGI:3606567
hm1
Allelic
Composition		 Lats2tm1Dgen/Lats2tm1Dgen
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lats2tm1Dgen mutation (1 available); any Lats2 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:101679 )
• homozygous embryos die possibly around E12.5




Genotype
MGI:3606568
ht2
Allelic
Composition		 Lats2tm1Dgen/Lats2+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lats2tm1Dgen mutation (1 available); any Lats2 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal startle reflex ( J:101679 )
• prepulse inhibition is significantly decreased




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory