Phenotypes associated with this allele

• Allele Symbol: Sostdc1^tm1Nit
• Allele Name: targeted mutation 1, Nobuyuki Itoh
• Allele ID: MGI:3604658
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sostdc1^tm1Nit/Sostdc1^tm1Nit	involves: 129S1/Sv * C57BL/6	MGI:3715854

Genotype
MGI:3715854

hm1

• Allelic Composition: Sostdc1^tm1Nit/Sostdc1^tm1Nit
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal molar crown morphology ( J:101382 )

• the buccal side had better developed connections or completely fused cusps anterior-posteriorly, forming a longitudinal crest with fused extra cusps

• crown development is accelerated in vitro compared to wild-type when exposed to BMP-4

abnormal molar cusp morphology ( J:101382 )

• highly altered cusp patterns

• fused buccal cusps forming an ectoloph

• extra cusps fused with the ectoloph, a lingual peg-shaped extra tooth

fused molars ( J:101382 )

• the first and second molars are often fused (in 22 of 52 mice)

• however, mice do not have occlusal problems

supernumerary molars ( J:101382 )

• an extra molar forms anterior to the first molar that develops faster than the more posterior teeth

abnormal enamel knot morphology ( J:101382 )

• enamel knots are enlarged

skeleton

abnormal molar crown morphology ( J:101382 )

• the buccal side had better developed connections or completely fused cusps anterior-posteriorly, forming a longitudinal crest with fused extra cusps

• crown development is accelerated in vitro compared to wild-type when exposed to BMP-4

abnormal molar cusp morphology ( J:101382 )

• highly altered cusp patterns

• fused buccal cusps forming an ectoloph

• extra cusps fused with the ectoloph, a lingual peg-shaped extra tooth

fused molars ( J:101382 )

• the first and second molars are often fused (in 22 of 52 mice)

• however, mice do not have occlusal problems

supernumerary molars ( J:101382 )

• an extra molar forms anterior to the first molar that develops faster than the more posterior teeth

abnormal enamel knot morphology ( J:101382 )

• enamel knots are enlarged

growth/size/body

abnormal molar crown morphology ( J:101382 )

• the buccal side had better developed connections or completely fused cusps anterior-posteriorly, forming a longitudinal crest with fused extra cusps

• crown development is accelerated in vitro compared to wild-type when exposed to BMP-4

abnormal molar cusp morphology ( J:101382 )

• highly altered cusp patterns

• fused buccal cusps forming an ectoloph

• extra cusps fused with the ectoloph, a lingual peg-shaped extra tooth

fused molars ( J:101382 )

• the first and second molars are often fused (in 22 of 52 mice)

• however, mice do not have occlusal problems

supernumerary molars ( J:101382 )

• an extra molar forms anterior to the first molar that develops faster than the more posterior teeth

abnormal enamel knot morphology ( J:101382 )

• enamel knots are enlarged