Phenotypes associated with this allele

• Allele Symbol: Npm1^tm2Ppp
• Allele Name: targeted mutation 2, Pier Paolo Pandolfi
• Allele ID: MGI:3604808
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Npm1^tm2Ppp/Npm1^tm2Ppp	involves: 129S1/Sv * C57BL/6	MGI:3606863

Genotype
MGI:3606863

hm1

• Allelic Composition: Npm1^tm2Ppp/Npm1^tm2Ppp
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:101494 )

• die at approximately E16.5

embryo

abnormal vitelline vasculature morphology ( J:101494 )

• show some hemoglobinization in the yolk sac but less than in controls

decreased embryo size ( J:101494 )

abnormal embryonic hematopoiesis ( J:101494 )

• display a similar albeit attenuated primitive hematopoiesis defect as homozygous Npm1^tm1Ppp mice

hematopoietic system

abnormal embryonic hematopoiesis ( J:101494 )

• display a similar albeit attenuated primitive hematopoiesis defect as homozygous Npm1^tm1Ppp mice

anemia ( J:101494 )

growth/size/body

decreased embryo size ( J:101494 )

nervous system

abnormal forebrain development ( J:101494 )

• anterior brain is not well formed

vision/eye

abnormal eye development ( J:101494 )

• eye is not well formed

cellular

decreased fibroblast proliferation ( J:101494 )

• early passage MEFs (P2-P6) have decreased cell proliferation rates

chromosome breakage ( J:101494 )

• MEFs exhibit high levels of tetraploidy and anueuploidy and contain supernumery centrosomes

cardiovascular system

abnormal vitelline vasculature morphology ( J:101494 )

• show some hemoglobinization in the yolk sac but less than in controls

integument

pallor ( J:101494 )