Phenotypes associated with this allele

• Allele Symbol: Vdr^tm1Tyam
• Allele Name: targeted mutation 1, Takeyoshi Yamashita
• Allele ID: MGI:3604810
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vdr^tm1Tyam/Vdr^tm1Tyam	involves: C57BL/6 * CBA	MGI:3715822

Genotype
MGI:3715822

hm1

• Allelic Composition: Vdr^tm1Tyam/Vdr^tm1Tyam
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating parathyroid hormone level ( J:101456 )

• at 6 weeks, 1399.6+/-194.8 pg/ml compared to 38.6+/-11.2 pg/ml in wild-type mice

decreased circulating calcium level ( J:101456 )

• at 6 weeks, 6.03+/-0.21 mg/dl compared to 9.18+/-0.12 mg/dl in wild-type mice

• however, when fed a high calcium diet mice recover normal calcium levels

decreased circulating phosphate level ( J:101456 )

• at 6 weeks, 6.96+/-0.44 mg/dl compared to 9.54+/-0.19 mg/dl in wild-type mice

abnormal vitamin D level ( J:101456 )

• vitamin D levels are increased (1206.2+/-14.1 pg/ml compared to 364.5+/-45.4 pg/ml in wild-type mice)

• treatment with FGF23 does not decreases vitamin D levels as it does in wild-type mice

skeleton

abnormal femur morphology ( J:101456 )

• femurs have enlarged metaphysis

short femur ( J:101456 )

increased width of hypertrophic chondrocyte zone ( J:101456 )

• the zone of hypertrophic chondrocytes in the growth plate is expanded

decreased bone mineral density of femur ( J:101456 )

• bone density of the femur is 277.9+/-10.5 mg/cm³ compared to 574.9+/-22.4 mg/cm³ in wild-type mice

growth/size/body

decreased body weight ( J:101456 )

• at 6 weeks, mice weigh less (23.6+/-1.0g) compared to wild-type mice (29.8+/-1.0g)

postnatal growth retardation ( J:101456 )

• by 6 weeks mice by 6 weeks mice

limbs/digits/tail

abnormal femur morphology ( J:101456 )

• femurs have enlarged metaphysis

short femur ( J:101456 )