Phenotypes associated with this allele

• Allele Symbol: Klhl6^tm1Sato
• Allele Name: targeted mutation 1, Thomas N Sato
• Allele ID: MGI:3604864
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Klhl6^tm1Sato/Klhl6^tm1Sato	either: (involves: 129T2/SvEms) or (involves: BALB/c) or (involves: CD-1)	MGI:3605617

Genotype
MGI:3605617

hm1

• Allelic Composition: Klhl6^tm1Sato/Klhl6^tm1Sato
• Genetic Background: either: (involves: 129T2/SvEms) or (involves: BALB/c) or (involves: CD-1)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell differentiation ( J:101363 )

• impaired development past the immature stage

decreased B cell number ( J:101363 )

• reduced number of B220+ and CD3- B lymphocytes in spleen and peripheral blood

decreased follicular B cell number ( J:101363 )

• 50% reduction in follicular B cells in the lymph nodes

abnormal spleen morphology ( J:101363 )

decreased spleen weight ( J:101363 )

• weight is reduced by about 20%

spleen hypoplasia ( J:101363 )

• number of splenocytes reduced by about 50%

abnormal lymph node germinal center morphology ( J:101363 )

• impaired germinal center formation

• lymph nodes fail to swell after ovalbumin immunization

abnormal adaptive immunity ( J:101363 )

• memory IgG response impaired while primary response is normal

hematopoietic system

abnormal B cell differentiation ( J:101363 )

• impaired development past the immature stage

decreased B cell number ( J:101363 )

• reduced number of B220+ and CD3- B lymphocytes in spleen and peripheral blood

decreased follicular B cell number ( J:101363 )

• 50% reduction in follicular B cells in the lymph nodes

abnormal spleen morphology ( J:101363 )

decreased spleen weight ( J:101363 )

• weight is reduced by about 20%

spleen hypoplasia ( J:101363 )

• number of splenocytes reduced by about 50%