All Phenotypes Sle1<NZW> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sle1^NZW
NZW
MGI:3604960

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Sle1^NZW/Sle1^NZW Tg(Tnfsf13b)1Fma/0	involves: C57BL/6 * DBA/2J * NZW	MGI:3789187
cx2	Sle1^NZW/Sle1^NZW Sles1^NZW/Sles1^NZW	involves: C57BL/6 * NZW	MGI:3604961

Allelic Composition	Sle1^NZW/Sle1^NZW Tg(Tnfsf13b)1Fma/0
Genetic Background	involves: C57BL/6 * DBA/2J * NZW

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sle1^NZW mutation (0 available); any Sle1 mutation (2 available)
Tg(Tnfsf13b)1Fma mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased B cell number ( J:134128 )

• increased total splenic B cell numbers

increased marginal zone B cell number ( J:134128 )

increased IgG level ( J:134128 )

• increased total serum IgG antibodies

increased IgM level ( J:134128 )

• increased total serum IgM antibodies

increased susceptibility to systemic lupus erythematosus ( J:134128 )

• increased serum IgG and IgM antibodies

• increased incidence of glomerulonephritis by 3 months of age

glomerulonephritis ( J:134128 )

• increased glomerulonephritis incidence at 3 months of age

renal/urinary system

glomerulonephritis ( J:134128 )

• increased glomerulonephritis incidence at 3 months of age

hematopoietic system

increased B cell number ( J:134128 )

• increased total splenic B cell numbers

increased marginal zone B cell number ( J:134128 )

increased IgG level ( J:134128 )

• increased total serum IgG antibodies

increased IgM level ( J:134128 )

• increased total serum IgM antibodies

Allelic Composition	Sle1^NZW/Sle1^NZW Sles1^NZW/Sles1^NZW
Genetic Background	involves: C57BL/6 * NZW

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sle1^NZW mutation (0 available); any Sle1 mutation (2 available)
Sles1^NZW mutation (0 available); any Sles1 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell physiology ( J:100678 )

• suppression of CD3+ T cell activation

• suppression of CD69 cell surface expression

decreased susceptibility to systemic lupus erythematosus ( J:100678 )

• suppression of anti-nuclear antibody production

hematopoietic system

abnormal T cell physiology ( J:100678 )

• suppression of CD3+ T cell activation

• suppression of CD69 cell surface expression

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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