Phenotypes associated with this allele

• Allele Symbol: Icam1^tm1Alb
• Allele Name: targeted mutation 1, Arthur L Beaudet
• Allele ID: MGI:3605161
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Icam1^tm1Alb/Icam1^tm1Alb	B6.Cg-Icam1^tm1Alb	MGI:3607143

Genotype
MGI:3607143

hm1

• Allelic Composition: Icam1^tm1Alb/Icam1^tm1Alb
• Genetic Background: B6.Cg-Icam1^tm1Alb

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal leukocyte adhesion ( J:100242 )

• leukocyte adhesion efficiency is significantly reduced in inflamed vessels compared to wildtype, is significantly increased compared with that of homozygous Itgal^tm1Bll mice, and is similar to that of homozygous Itgam^tm1Bll mice

• treatment with Itgal antibodies decreases adhesion efficiency and arrest

• 33% of leukocytes adhere to endothelium compared to 95% in wildtype, with adherence decreasing to 20% in the presence of Itgal antibodies

abnormal leukocyte tethering or rolling ( J:100242 )

• average rolling velocity of leukocytes after TNF-alpha induced inflammation in venules does not differ from wild-type, however treatment with Itgal (LFA-1) antibodies, but not Itgam (Mac-1) antibodies, increases rolling velocity

increased leukocyte cell number ( J:100242 )

• total leukocyte numbers, polymorphonuclear cell numbers and mononuclear cell numbers are increased

increased neutrophil cell number ( J:100242 )

• 3-fold increase in the number of circulating neutrophils

hematopoietic system

abnormal leukocyte adhesion ( J:100242 )

• leukocyte adhesion efficiency is significantly reduced in inflamed vessels compared to wildtype, is significantly increased compared with that of homozygous Itgal^tm1Bll mice, and is similar to that of homozygous Itgam^tm1Bll mice

• treatment with Itgal antibodies decreases adhesion efficiency and arrest

• 33% of leukocytes adhere to endothelium compared to 95% in wildtype, with adherence decreasing to 20% in the presence of Itgal antibodies

abnormal leukocyte tethering or rolling ( J:100242 )

• average rolling velocity of leukocytes after TNF-alpha induced inflammation in venules does not differ from wild-type, however treatment with Itgal (LFA-1) antibodies, but not Itgam (Mac-1) antibodies, increases rolling velocity

increased leukocyte cell number ( J:100242 )

• total leukocyte numbers, polymorphonuclear cell numbers and mononuclear cell numbers are increased

increased neutrophil cell number ( J:100242 )

• 3-fold increase in the number of circulating neutrophils

cellular

abnormal leukocyte adhesion ( J:100242 )

• leukocyte adhesion efficiency is significantly reduced in inflamed vessels compared to wildtype, is significantly increased compared with that of homozygous Itgal^tm1Bll mice, and is similar to that of homozygous Itgam^tm1Bll mice

• treatment with Itgal antibodies decreases adhesion efficiency and arrest

• 33% of leukocytes adhere to endothelium compared to 95% in wildtype, with adherence decreasing to 20% in the presence of Itgal antibodies

abnormal leukocyte tethering or rolling ( J:100242 )

• average rolling velocity of leukocytes after TNF-alpha induced inflammation in venules does not differ from wild-type, however treatment with Itgal (LFA-1) antibodies, but not Itgam (Mac-1) antibodies, increases rolling velocity