homeostasis/metabolism
• at 6 and 24 h after i.p. injection of LPS, 6- to 8-wk-old heterozygotes develop significantly higher levels of proteinuria than similarly treated wild-type controls
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• in response to LPS-induced kidney injury, heterozygotes on the C57BL/6 background develop significantly higher levels of proteinuria at 6 and 24 h after i.p. injection of LPS than similarly treated wild-type controls
• however, heterozygotes on the C57BL/6 background do not develop albuminuria after tail vein injection of adriamycin, similar to wild-type controls
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renal/urinary system
N |
• heterozygotes show no evidence of spontaneous proteinuria at 6-8 weeks of age and do not develop glomerular pathology up to 12 months of age
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• at 6 and 24 h after i.p. injection of LPS, 6- to 8-wk-old heterozygotes develop significantly higher levels of proteinuria than similarly treated wild-type controls
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