Phenotypes associated with this allele

• Allele Symbol: Npas3^tm1Ewb
• Allele Name: targeted mutation 1, Eric W Brunskill
• Allele ID: MGI:3605473
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Npas3^tm1Ewb/Npas3^tm1Ewb	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3606246

Genotype
MGI:3606246

hm1

• Allelic Composition: Npas3^tm1Ewb/Npas3^tm1Ewb
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavioral response to xenobiotic ( J:101561 )

• behavioral responses to methamphetamine, haloperidol, quinpirole, SCH23390, SKF81297, clozapine, and MK-801 are abnormal indicating abnormalities in dopamine and glutamate signaling

• however, dopamine and glutamate receptor numbers are normal

decreased anxiety-related response ( J:101561 )

• homozygotes show less hesitation before entering open zones (54% decrease in stretch-attend movements) and spend 50% more time in the open zones in an elevated zero-maze, but are not hyperactive in this maze

abnormal response to novelty ( J:101561 )

increased exploration in new environment ( J:101561 )

• homozygotes display increased activity and fail to habituate when placed in an open field

abnormal response to novel object ( J:101561 )

• homozygotes spend significantly less time investigating a novel object

abnormal reflex ( J:101561 )

abnormal startle reflex ( J:101561 )

• prepulse inhibition of the startle reflex by prepulses of 74- and 76-dB are reduced to 64% compared to 92% inhibition in wild-type mice

limb grasping ( J:101561 )

• when lifted by the tail homozygotes clasp their limbs and do not struggle

impaired coordination ( J:101561 )

• homozygotes have more difficulty crossing a beam than wild-type mice

abnormal gait ( J:101561 )

• shorter, narrower strides and improper foot placement is seen

short stride length ( J:101561 )

abnormal nest building behavior ( J:101561 )

• homozygotes do not build normal nests and scatter or ignore nesting material

nervous system

abnormal cerebellar foliation ( J:101561 )

enlarged fourth ventricle ( J:101561 )

• the posterior fourth ventricle is enlarged

enlarged lateral ventricles ( J:101561 )

• the posterior lateral ventricle is enlarged

enlarged third ventricle ( J:101561 )

• the posterior third ventricle is enlarged

enlarged cerebral aqueduct ( J:101561 )

• the aqueduct of Sylvius (connects the third and fourth ventricles) is enlarged

abnormal corpus callosum morphology ( J:101561 )

• decreased commissural fibers are seen in the corpus callosum

abnormal cingulate gyrus morphology ( J:101561 )

• the cingulate cortex is abnormal

abnormal retrosplenial region morphology ( J:101561 )

• the retrosplenial cortex is abnormal

abnormal hippocampus morphology ( J:101561 )

• the anterior hippocampus is reduced in size

growth/size/body

decreased body weight ( J:101561 )

• homozygotes weigh about 20% less than wild-type mice