All Phenotypes Prdm1<tm1.1Clme> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prdm1^tm1.1Clme/Prdm1^tm1.1Clme	involves: 129S1/Sv * 129X1/SvJ * FVB/N * ICR	MGI:3606169
ht2	Prdm1^tm1.1Clme/Prdm1⁺	involves: 129S1/Sv * 129X1/SvJ * FVB/N * ICR	MGI:3606170
ht3	Prdm1^tm1.1Clme/Prdm1^tm2Rob	involves: 129S/Sv * 129X1/Sv * C57BL/6 * FVB/N * ICR	MGI:3606172
ht4	Prdm1^tm1.1Clme/Prdm1^tm1.1Liz	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ	MGI:4366875
ht5	Prdm1^tm1.1Clme/Prdm1^tm2.1Liz	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ	MGI:4366877

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:101718 )

• homozygous embryos die at E10.5

embryo

abnormal pharyngeal arch morphology ( J:101718 )

• at E9.5 a single branchial arch is present unlike wild-type mice which have 3 arches; however, specification and migration of neural crest cells is normal

• selective cell death occurs in the mesenchyme cells at the site where the 2nd and 3rd arches normally emerge

• however, in the limb bud patterning of the zone of polarizing activity and the apical ectodermal ridge is normal and the otic vesicle forms normally

abnormal pharyngeal arch mesenchyme morphology ( J:101718 )

• selective cell death occurs in the mesenchyme cells at the site where the 2nd and 3rd arches normally emerge

absent second pharyngeal arch ( J:101718 )

• at E9.5

absent third pharyngeal arch ( J:101718 )

• at E9.5

decreased embryo size ( J:101718 )

• seen at E9.5

abnormal placenta labyrinth morphology ( J:101718 )

• at E9.5, the labyrinthine region fails to expand correctly reducing the volume of blood spaces

reproductive system

decreased primordial germ cell number ( J:101718 )

• at the headfold stage (E7.75) 2-4 or no primordial germs cells are detected and at E9.0-9.5, no primordial germ cells are detected

cardiovascular system

abnormal dorsal aorta morphology ( J:101718 )

• hemorrhaging with blood pooling in dorsal aorta is observed at E10.5

hemorrhage ( J:101718 )

• at E10.5, severe hemorrhaging is seen with blood pooling in the heart, dorsal aorta and under the surface ectoderm, but at E9.5 development of the heart and blood vessels appears normal

muscle

abnormal dermomyotome development ( J:101718 )

• at E10.5, the Fgf8 domain in the epaxial dermomyotomal lip is expanded

growth/size/body

abnormal pharyngeal arch mesenchyme morphology ( J:101718 )

• selective cell death occurs in the mesenchyme cells at the site where the 2nd and 3rd arches normally emerge

decreased embryo size ( J:101718 )

• seen at E9.5

craniofacial

abnormal pharyngeal arch morphology ( J:101718 )

• at E9.5 a single branchial arch is present unlike wild-type mice which have 3 arches; however, specification and migration of neural crest cells is normal

• selective cell death occurs in the mesenchyme cells at the site where the 2nd and 3rd arches normally emerge

• however, in the limb bud patterning of the zone of polarizing activity and the apical ectodermal ridge is normal and the otic vesicle forms normally

abnormal pharyngeal arch mesenchyme morphology ( J:101718 )

• selective cell death occurs in the mesenchyme cells at the site where the 2nd and 3rd arches normally emerge

absent second pharyngeal arch ( J:101718 )

• at E9.5

absent third pharyngeal arch ( J:101718 )

• at E9.5

cellular

decreased primordial germ cell number ( J:101718 )

• at the headfold stage (E7.75) 2-4 or no primordial germs cells are detected and at E9.0-9.5, no primordial germ cells are detected

Allelic Composition	Prdm1^tm1.1Clme/Prdm1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * FVB/N * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prdm1^tm1.1Clme mutation (0 available); any Prdm1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

decreased primordial germ cell number ( J:101718 )

• at E7.75 and E9.0-9.5, the number of primordial germ cells is reduced and extrapolation indicates that the founding population of primordial germ cells is reduced by 78% compared to wild-type mice, 9 cells versus 40 cells in wild-type

cellular

decreased primordial germ cell number ( J:101718 )

Allelic Composition	Prdm1^tm1.1Clme/Prdm1^tm2Rob
Genetic Background	involves: 129S/Sv * 129X1/Sv * C57BL/6 * FVB/N * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prdm1^tm1.1Clme mutation (0 available); any Prdm1 mutation (66 available)
Prdm1^tm2Rob mutation (0 available); any Prdm1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:101718 )

• die at E10.5

embryo

abnormal pharyngeal arch morphology ( J:101718 )

• at E9.5 a single branchial arch is present unlike wild-type mice which have 3 arches; however, specification and migration of neural crest cells is normal

• selective cell death occurs in the mesenchyme cells at the site where the 2nd and 3rd arches normally emerge

• however, in the limb bud patterning of the zone of polarizing activity and the apical ectodermal ridge is normal and the otic vesicle forms normally

abnormal pharyngeal arch mesenchyme morphology ( J:101718 )

• selective cell death occurs in the mesenchyme cells at the site where the 2nd and 3rd arches normally emerge

absent second pharyngeal arch ( J:101718 )

• at E9.5

absent third pharyngeal arch ( J:101718 )

• at E9.5

decreased embryo size ( J:101718 )

• seen at E9.5

abnormal placenta labyrinth morphology ( J:101718 )

• at E9.5, the labyrinthine region fails to expand correctly reducing the volume of blood spaces

reproductive system

absent primordial germ cells ( J:101718 )

• at the headfold stage (E7.75) 2-4 or no primordial germs cells are detected and at E9.0-9.5, no primordial germ cells are detected

cardiovascular system

abnormal dorsal aorta morphology ( J:101718 )

• hemorrhaging with blood pooling in dorsal aorta is observed at E10.5

hemorrhage ( J:101718 )

• at E10.5, severe hemorrhaging is seen with blood pooling in the heart, dorsal aorta and under the surface ectoderm, but at E9.5 development of the heart and blood vessels appears normal

muscle

abnormal dermomyotome development ( J:101718 )

• at E10.5, the Fgf8 domain in the epaxial dermomyotomal lip is expanded

growth/size/body

abnormal pharyngeal arch mesenchyme morphology ( J:101718 )

• selective cell death occurs in the mesenchyme cells at the site where the 2nd and 3rd arches normally emerge

decreased embryo size ( J:101718 )

• seen at E9.5

craniofacial

abnormal pharyngeal arch morphology ( J:101718 )

• at E9.5 a single branchial arch is present unlike wild-type mice which have 3 arches; however, specification and migration of neural crest cells is normal

• selective cell death occurs in the mesenchyme cells at the site where the 2nd and 3rd arches normally emerge

• however, in the limb bud patterning of the zone of polarizing activity and the apical ectodermal ridge is normal and the otic vesicle forms normally

abnormal pharyngeal arch mesenchyme morphology ( J:101718 )

• selective cell death occurs in the mesenchyme cells at the site where the 2nd and 3rd arches normally emerge

absent second pharyngeal arch ( J:101718 )

• at E9.5

absent third pharyngeal arch ( J:101718 )

• at E9.5

cellular

absent primordial germ cells ( J:101718 )

• at the headfold stage (E7.75) 2-4 or no primordial germs cells are detected and at E9.0-9.5, no primordial germ cells are detected

Allelic Composition	Prdm1^tm1.1Clme/Prdm1^tm1.1Liz
Genetic Background	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prdm1^tm1.1Clme mutation (0 available); any Prdm1 mutation (66 available)
Prdm1^tm1.1Liz mutation (2 available); any Prdm1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal germ cell morphology ( J:153979 )

• 12 of 13 mice exhibit germ cell defects

absent oocytes ( J:153979 )

azoospermia ( J:153979 )

• testes lack spermatocytes

decreased primordial germ cell number ( J:153979 )

• slightly at E9.5

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:153979 )

• although normally represented at E10.5, fewer than expected mice are present at E14.5

postnatal lethality, incomplete penetrance ( J:153979 )

• fewer than expected mice are found at weaning

reproductive system

abnormal germ cell morphology ( J:153979 )

• 12 of 13 mice exhibit germ cell defects

absent oocytes ( J:153979 )

azoospermia ( J:153979 )

• testes lack spermatocytes

decreased primordial germ cell number ( J:153979 )

• slightly at E9.5

decreased testis weight ( J:153979 )

limbs/digits/tail

forelimb oligodactyly ( J:153979 )

• mice exhibit a rudimentary or missing fifth digit on the forelimb unlike wild-type mice

endocrine/exocrine glands

decreased testis weight ( J:153979 )

Allelic Composition	Prdm1^tm1.1Clme/Prdm1^tm2.1Liz
Genetic Background	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prdm1^tm1.1Clme mutation (0 available); any Prdm1 mutation (66 available)
Prdm1^tm2.1Liz mutation (2 available); any Prdm1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:153979 )

• mice exhibit no visible phenotype

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