All Phenotypes Grm6<nob3> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Grm6^nob3
no b wave 3
MGI:3605835

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grm6^nob3/Grm6^nob3	B6.B10(D2)-Grm6^nob3/Pjn	MGI:4880773
ht2	Grm6^nob3/Grm6^nob4	involves: C57BL/6J * C57BL/10 * DBA/2	MGI:4880735
ht3	Grm6^nob3/Grm6^nob7	involves: C57BL/6J * C57BL/10J	MGI:5755378
cx4	Gpr179^nob5/Gpr179⁺ Grm6^nob3/Grm6⁺	involves: C3H * C57BL/10	MGI:5568985

Allelic Composition	Grm6^nob3/Grm6^nob3
Genetic Background	B6.B10(D2)-Grm6^nob3/Pjn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grm6^nob3 mutation (1 available); any Grm6 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:152828 )

N	• mice exhibit normal retinal lamination and morphology

abnormal eye physiology ( J:152828 )

• under scotopic and photopic conditions, contrast sensitivity is lower than in wild-type mice

• spatial frequency threshold is lower than in wild-type mice

• the spatial frequency cutoffs are lower than in wild-type mice

• retinal ganglion cell visual responses to light onset are abnormal compared to in wild-type mice

• ON retinal ganglion cell responses are ill-defined and delayed compared to in wild-type mice

• however, peak contrast sensitivity is normal

abnormal cone electrophysiology ( J:152828 )

• photopic b-waves are absent

• however, a-waves are normal

abnormal rod electrophysiology ( J:152828 )

• scotopic b-waves are absent

• mice lack a scotopic threshold response unlike wild-type mice

• however, a-waves are normal

Allelic Composition	Grm6^nob3/Grm6^nob4
Genetic Background	involves: C57BL/6J * C57BL/10 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grm6^nob3 mutation (1 available); any Grm6 mutation (53 available)
Grm6^nob4 mutation (0 available); any Grm6 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal eye physiology ( J:152828 )

• spatial frequency threshold is lower than in wild-type mice

• the spatial frequency cutoffs are lower than in wild-type mice

• however, peak contrast sensitivity is normal

abnormal cone electrophysiology ( J:152828 )

• photopic b-waves are absent

• however, a-waves are normal

abnormal rod electrophysiology ( J:152828 )

• scotopic b-waves are absent

• mice lack a scotopic threshold response unlike wild-type mice

• however, a-waves are normal

Allelic Composition	Grm6^nob3/Grm6^nob7
Genetic Background	involves: C57BL/6J * C57BL/10J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grm6^nob3 mutation (1 available); any Grm6 mutation (53 available)
Grm6^nob7 mutation (0 available); any Grm6 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

decreased b-wave amplitude ( J:229885 )

• electroretinography has no b wave component under dark or light adapted conditions

abnormal cone electrophysiology ( J:229885 )

• photopic b waves are absent and cone ERGs are electronegative

abnormal rod electrophysiology ( J:229885 )

• scotopic b waves are absent, and the a wave is followed by a negative component, slow PIII

Allelic Composition	Gpr179^nob5/Gpr179⁺ Grm6^nob3/Grm6⁺
Genetic Background	involves: C3H * C57BL/10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr179^nob5 mutation (0 available); any Gpr179 mutation (71 available)
Grm6^nob3 mutation (1 available); any Grm6 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal rod electrophysiology ( J:209941 )

• reduced b-wave in dark-adapted mice

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