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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fgfr1tm1Swnr
targeted mutation 1, Sabine Werner
MGI:3606056
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fgfr1tm1Swnr/Fgfr1tm1Swnr involves: 129S7/SvEvBrd * C57BL/6 MGI:3606972
cn2
 		Fgfr1tm1Swnr/Fgfr1tm1Swnr
Fgfr2tm1Dor/Fgfr2tm1Dor
Tg(KRT5-cre)5132Jlj/0 		involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J MGI:5642123


Genotype
MGI:3606972
hm1
Allelic
Composition		 Fgfr1tm1Swnr/Fgfr1tm1Swnr
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1Swnr mutation (0 available); any Fgfr1 mutation (223 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
integument phenotype ( J:101854 )
N
• homozygotes are viable and fertile and analysis of skin and wound healing experiments reveal no obvious skin abnormalities




Genotype
MGI:5642123
cn2
Allelic
Composition		 Fgfr1tm1Swnr/Fgfr1tm1Swnr
Fgfr2tm1Dor/Fgfr2tm1Dor
Tg(KRT5-cre)5132Jlj/0
Genetic
Background		 involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1Swnr mutation (0 available); any Fgfr1 mutation (223 available)
Fgfr2tm1Dor mutation (3 available); any Fgfr2 mutation (90 available)
Tg(KRT5-cre)5132Jlj mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body size ( J:158802 )

integument
abnormal skin adnexa morphology ( J:158802 )
• progressive loss of skin appendages
progressive hair loss ( J:158802 )
• progressive hair loss such that mice are hairless by 1 month of age
acanthosis ( J:158802 )
• mice develop epidermal hyperthickening combined with disorganization of the keratinocytes which progresses with age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory