Phenotypes associated with this allele

• Allele Symbol: Hr^USP
• Allele Name: hairless USP
• Allele ID: MGI:3606124
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hr^USP/Hr^USP	either: (involves: A/J * BALB/c) or (involves: BALB/c * C57BL/6) or (involves: BALB/c * DBA/2)	MGI:3606992

Genotype
MGI:3606992

hm1

• Allelic Composition: Hr^USP/Hr^USP
• Genetic Background: either: (involves: A/J * BALB/c) or (involves: BALB/c * C57BL/6) or (involves: BALB/c * DBA/2)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

thymus cortex atrophy ( J:21316 )

• thymus exhibits more intense cortical atrophy than controls after 3 months of age

abnormal thymus involution ( J:21316 )

• acceleration in the rate of thymus involution

abnormal immunoglobulin level ( J:21316 )

increased IgG level ( J:21316 )

decreased IgM level ( J:21316 )

• slight decrease in IgM levels

abnormal lymph node secondary follicle morphology ( J:21316 )

• hyperplasia of lymph node follicles and prominent germinal centers

lymph node medullary cord hyperplasia ( J:21316 )

• hyperplasia of medullary cords

enlarged inguinal lymph nodes ( J:21316 )

• inguinal lymph nodes are 10 times the normal size

enlarged popliteal lymph nodes ( J:21316 )

• popliteal lymph nodes are twice the normal size

lymph node inflammation ( J:21316 )

increased susceptibility to autoimmune disorder ( J:21316 )

• develop autoimmune lesions later in life

glomerulonephritis ( J:21316 )

• exhibit membranoproliferative glomerulonephritis after 1 year of age, characterized by thickening of the basmement membrane and an increase in glomerular cell number

renal/urinary system

glomerulonephritis ( J:21316 )

• exhibit membranoproliferative glomerulonephritis after 1 year of age, characterized by thickening of the basmement membrane and an increase in glomerular cell number

liver/biliary system

abnormal hepatocyte morphology ( J:21316 )

• hepatocytes show vacuolation and cell pleomorphism

hematopoietic system

thymus cortex atrophy ( J:21316 )

• thymus exhibits more intense cortical atrophy than controls after 3 months of age

abnormal thymus involution ( J:21316 )

• acceleration in the rate of thymus involution

abnormal immunoglobulin level ( J:21316 )

increased IgG level ( J:21316 )

decreased IgM level ( J:21316 )

• slight decrease in IgM levels

integument

alopecia ( J:21316 , J:101827 )

• lose the first haircoat about three weeks after birth which is never replaced (J:21316)

thin hypodermis ( J:101827 )

• hypodermis is scant at 90 days of age

long toenails ( J:21316 , J:101827 )

• nails grow continuously and become curved (J:101827)

abnormal hair follicle morphology ( J:21316 )

dilated hair follicle ( J:101827 )

• dilated hair follicles are seen in the dermis by 30 days of age

hair follicle degeneration ( J:101827 )

• atrophic hair follicles are observed by 30 days of age and no functional hair follicles are seen at 90 days of age

abnormal skin morphology ( J:101827 )

abnormal dermal layer morphology ( J:101827 )

• dermal connective tissue is scant at 240 days of age

thick dermal layer ( J:101827 )

• dermis is significantly thicker by 240 days of age

hyperkeratosis ( J:101827 )

• exhibit hyperkeratosis by 18 days of age that becomes more pronounced over time

wrinkled skin ( J:21316 , J:101827 )

• skin becomes wrinkled after 3 weeks of age (J:21316)

• skin expansion with aging interfered with mobility and could cover the eyes, restricting vision (J:21316)

abnormal skin condition ( J:21316 , J:101827 )

• skin becomes irregular and viscous (J:101827)

dermal cyst ( J:21316 , J:101827 )

• dermis is rich in cyst-like structures that are connected to sebaceous glands (J:21316)

• develop dermal cysts and utricles by 18 days of age which become larger over time and eventually occupy most of the dermis and extend into the deep dermis (J:101827)

• dermal cysts and utricles are filled with lamellae of keratin at 18 days of age, however less keratin is seen within the dermal cysts over time so that by 240 days of age, they contain almost no keratin (J:101827)

thick skin ( J:21316 , J:101827 )

• skin becomes thickened after 3 weeks of age (J:21316)

endocrine/exocrine glands

thymus cortex atrophy ( J:21316 )

• thymus exhibits more intense cortical atrophy than controls after 3 months of age

abnormal thymus involution ( J:21316 )

• acceleration in the rate of thymus involution

growth/size/body

dermal cyst ( J:21316 , J:101827 )

• dermis is rich in cyst-like structures that are connected to sebaceous glands (J:21316)

• develop dermal cysts and utricles by 18 days of age which become larger over time and eventually occupy most of the dermis and extend into the deep dermis (J:101827)

• dermal cysts and utricles are filled with lamellae of keratin at 18 days of age, however less keratin is seen within the dermal cysts over time so that by 240 days of age, they contain almost no keratin (J:101827)

limbs/digits/tail

long toenails ( J:21316 , J:101827 )

• nails grow continuously and become curved (J:101827)