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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		P2rx7tm1Ipch
targeted mutation 1, Iain P Chessell
MGI:3606250
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		P2rx7tm1Ipch/P2rx7tm1Ipch B6.Cg-P2rx7tm1Ipch MGI:3608499
hm2
 		P2rx7tm1Ipch/P2rx7tm1Ipch involves: 129 MGI:4358418
hm3
 		P2rx7tm1Ipch/P2rx7tm1Ipch involves: 129 * C57BL/6 MGI:4358421
hm4
 		P2rx7tm1Ipch/P2rx7tm1Ipch involves: 129 * C57BL/6 * DBA MGI:4939416


Genotype
MGI:3608499
hm1
Allelic
Composition		 P2rx7tm1Ipch/P2rx7tm1Ipch
Genetic
Background		 B6.Cg-P2rx7tm1Ipch
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
P2rx7tm1Ipch mutation (0 available); any P2rx7 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal pain threshold ( J:101945 )
• in mutant mice development of both thermal and mechanical hypersensitivity was completely absent following nerve ligation
• nociceptive processing in the absence of any neuropathic or inflammatory insult was normal

immune system
abnormal inflammatory response ( J:101945 )
• mutant mice failed to develop significant hypersensitivity at any time after Freund's Complete Adjuvant ?induced inflammation




Genotype
MGI:4358418
hm2
Allelic
Composition		 P2rx7tm1Ipch/P2rx7tm1Ipch
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
P2rx7tm1Ipch mutation (0 available); any P2rx7 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:97422 )
N
• radical-mediated bacterial killing in macrophages is normal




Genotype
MGI:4358421
hm3
Allelic
Composition		 P2rx7tm1Ipch/P2rx7tm1Ipch
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
P2rx7tm1Ipch mutation (0 available); any P2rx7 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:118561 )
• unlike wild-type cells, macrophages are not killed by ATP stimulation over a 16-hour period
• bone marrow-derived macrophages infected with bacille Calmette-Guerin and stimulated with ATP exhibit decreased killing of the mycobacteria compared with similarly treated wild-type cells
• macrophages fail to form coalesced and acidified multibacillary vacuoles unlike in similarly infected and stimulated wild-type cells

hematopoietic system
abnormal macrophage physiology ( J:118561 )
• unlike wild-type cells, macrophages are not killed by ATP stimulation over a 16-hour period
• bone marrow-derived macrophages infected with bacille Calmette-Guerin and stimulated with ATP exhibit decreased killing of the mycobacteria compared with similarly treated wild-type cells
• macrophages fail to form coalesced and acidified multibacillary vacuoles unlike in similarly infected and stimulated wild-type cells




Genotype
MGI:4939416
hm4
Allelic
Composition		 P2rx7tm1Ipch/P2rx7tm1Ipch
Genetic
Background		 involves: 129 * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
P2rx7tm1Ipch mutation (0 available); any P2rx7 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:107324 )
N
• mice exhibit normal response to carotid ligation




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory