Phenotypes associated with this allele

• Allele Symbol: Cpt1a^tm1Pwo
• Allele Name: targeted mutation 1, Philip A Wood
• Allele ID: MGI:3606251
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cpt1a^tm1Pwo/Cpt1a^tm1Pwo	either: 129S6/SvEvTac-Cpt1a^tm1Pwo or (involves: 129S6/SvEvTac * C57BL/6NTac)	MGI:3606424
ht2	Cpt1a^tm1Pwo/Cpt1a^+	either: 129S6/SvEvTac-Cpt1a^tm1Pwo or (involves: 129S6/SvEvTac * C57BL/6NTac)	MGI:3606425

Genotype
MGI:3606424

hm1

• Allelic Composition: Cpt1a^tm1Pwo/Cpt1a^tm1Pwo
• Genetic Background: either: 129S6/SvEvTac-Cpt1a^tm1Pwo or (involves: 129S6/SvEvTac * C57BL/6NTac)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:101934 )

• homozygotes die before E10

Genotype
MGI:3606425

ht2

• Allelic Composition: Cpt1a^tm1Pwo/Cpt1a⁺
• Genetic Background: either: 129S6/SvEvTac-Cpt1a^tm1Pwo or (involves: 129S6/SvEvTac * C57BL/6NTac)

homeostasis/metabolism

decreased circulating glucose level ( J:101934 )

• after a 24 hour fast serum glucose levels are significantly decreased compared to wild-type mice

increased circulating free fatty acids level ( J:101934 )

• after a 24 hour fast serum free fatty acid levels are significantly increased compared to wild-type mice

reproductive system

transmission ratio distortion ( J:101934 )

• when heterozygotes are crossed to heterozygotes more than the expected percentage of heterozygous pups are found, greater than 80% compared to the expected 67%

• however, when heterozygotes are crossed to wild-type mice no significant deviation from the expected ratio of heterozygous to wild-type offspring is seen

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
carnitine palmitoyltransferase I deficiency		DOID:0090129	OMIM:255120	J:101934