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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ccl24tm1Mer
targeted mutation 1, Marc E Rothenberg
MGI:3606463
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ccl24tm1Mer/Ccl24tm1Mer 129S.129S6-Ccl24tm1Mer MGI:3606467
hm2
 		Ccl24tm1Mer/Ccl24tm1Mer involves: 129S6/SvEvTac * C57BL/6J MGI:3606469
cx3
 		Ccl11tm1Mer/Ccl11tm1Mer
Ccl24tm1Mer/Ccl24tm1Mer 		129S.129S6(Cg)-Ccl24tm1Mer Ccl11tm1Mer MGI:3606496
cx4
 		Ccl11tm1Mer/Ccl11tm1Mer
Ccl24tm1Mer/Ccl24tm1Mer 		involves: 129S6/SvEvTac MGI:4847669


Genotype
MGI:3606467
hm1
Allelic
Composition		 Ccl24tm1Mer/Ccl24tm1Mer
Genetic
Background		 129S.129S6-Ccl24tm1Mer
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccl24tm1Mer mutation (0 available); any Ccl24 mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immune system physiology ( J:98708 , J:102034 )
• Background Sensitivity: interleukin-13-induced eosinophil migration to the lung raised eosinophil numbers in bronchoalveolar lavage fluid 9-fold less in mutant than in wildtype mice (J:98708)
• Upon a second intranasal ovalbumin challenge after initial intraperitoneal sensitization, mutant mice exhibit a 4-fold greater elevation in peripheral blood eosinophil counts than do similarly challenged wild-type controls (J:102034)
• Upon a second intranasal ovalbumin challenge after initial intraperitoneal sensitization, mutant mice have 4-fold fewer eosinophils in bronchoalveolar lavage fluid (BALF) than do similarly challenged wild-type controls (J:102034)




Genotype
MGI:3606469
hm2
Allelic
Composition		 Ccl24tm1Mer/Ccl24tm1Mer
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccl24tm1Mer mutation (0 available); any Ccl24 mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immune system physiology ( J:98708 )
• Background Sensitivity: interleukin-13-induced eosinophil migration to the lung raised their numbers in bronchoalveolar lavage fluid 50-fold less in mutant than in wildtype mice - background dependent




Genotype
MGI:3606496
cx3
Allelic
Composition		 Ccl11tm1Mer/Ccl11tm1Mer
Ccl24tm1Mer/Ccl24tm1Mer
Genetic
Background		 129S.129S6(Cg)-Ccl24tm1Mer Ccl11tm1Mer
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccl11tm1Mer mutation (3 available); any Ccl11 mutation (14 available)
Ccl24tm1Mer mutation (0 available); any Ccl24 mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immune system physiology ( J:102034 )
• doubly mutant mice have 1.5-2-fold as many eosinophils in the bone marrow and peripheral blood as do wild-type 129S/SvEv mice
• doubly mutant mice have 85-fold fewer eosinophils in the jejunum than do wild-type 129S/SvEv mice
abnormal inflammatory response ( J:102034 )
• upon a second intranasal ovalbumin challenge after initial intraperitoneal sensitization, doubly mutant mice exhibit a 10-fold greater elevation in peripheral blood eosinophil counts than do similarly challenged wild-type controls
• upon a second intranasal ovalbumin challenge after initial intraperitoneal sensitization, doubly mutant mice have 7-fold fewer eosinophils in bronchoalveolar lavage fluid (BALF) than do similarly challenged wild-type controls and significantly fewer than mice mutant only for Ccl24 (p<0.01) or Ccl11 (p<0.05); numbers of BALF noneosinophils do not differ between mutant and wild-type mice
• upon a second intranasal ovalbumin challenge after initial intraperitoneal sensitization, doubly mutant mice have 85% fewer peribronchial eosinophils than wild-type or singly mutant mice; the double mutants have eosinophils scattered in the lung parenchyma, rather than concentrated in peribronchial and perivascular inflammatory infiltrates as in wild-type and singly mutant mice




Genotype
MGI:4847669
cx4
Allelic
Composition		 Ccl11tm1Mer/Ccl11tm1Mer
Ccl24tm1Mer/Ccl24tm1Mer
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccl11tm1Mer mutation (3 available); any Ccl11 mutation (14 available)
Ccl24tm1Mer mutation (0 available); any Ccl24 mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:115273 )
N
• lymphocyte and macrophage accumulation in bronchoalveolar fluid is unaffected
decreased eosinophil cell number ( J:115273 )
• eosinophils are absent in bronchoalveolar lavage fluid after Aspergillus fumigatus exposure

immune system
decreased eosinophil cell number ( J:115273 )
• eosinophils are absent in bronchoalveolar lavage fluid after Aspergillus fumigatus exposure

respiratory system
abnormal respiratory system physiology ( J:115273 )
• reduced mucus production after Aspergillus fumigatus exposure




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory