Phenotypes associated with this allele

• Allele Symbol: Acrbp^tm1Wen
• Allele Name: targeted mutation 1, Wolfgang Engel
• Allele ID: MGI:3606887
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Acrbp^tm1Wen/Acrbp^tm1Wen	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)	MGI:3607346

Genotype
MGI:3607346

hm1

• Allelic Composition: Acrbp^tm1Wen/Acrbp^tm1Wen
• Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

delayed fertilization ( J:102079 )

• although sperm from homozygotes are able to penetrate oocytes, they exhibit a delay in penetration of the zona pellucida in IVF assays

impaired fertilization ( J:102079 )

• sperm from homozygous mice show a reduced in vitro fertilization rate of wild-type DMSO or aroclor-1254 treated (to harden the zona pellucida) oocytes, aged oocytes, and oocytes from backgrounds with a thick zona pellucida