Phenotypes associated with this allele

• Allele Symbol: Cep57⁺
• Allele Name: wild type
• Allele ID: MGI:3606942
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Cep57^em1Jvd/Cep57^+	involves: 129 * C57BL/6	MGI:6208867
ht2	Cep57^em2Jvd/Cep57^+	involves: FVB/N	MGI:6208870

Genotype
MGI:6208867

ht1

• Allelic Composition: Cep57^em1Jvd/Cep57⁺
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell morphology ( J:264300 )

• intermediate levels of supernumerary centrioles in brain, lung, liver, intestine, kidney, skin and lower back soft tissue cells without affecting apoptosis rates

aneuploidy ( J:264300 )

• intermediate rates in hematopoietic cells

• however, rates are normal in lung, liver, kidney, skin, brain and lumbar vertebrae cells

neoplasm

increased tumor incidence ( J:264300 )

• tumors in more than half of mice at 16 months of age, with lung adenomas the more prevalent

• however, tumor spectrum is otherwise normal

increased incidence of tumors by chemical induction ( J:264300 )

• induced by DMBA

increased lung adenoma incidence ( J:264300 )

• with increased aneuploidy compared with normal tissue

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:264300 )

• induced by DMBA

respiratory system

increased lung adenoma incidence ( J:264300 )

• with increased aneuploidy compared with normal tissue

Genotype
MGI:6208870

ht2

• Allelic Composition: Cep57^em2Jvd/Cep57⁺
• Genetic Background: involves: FVB/N

neoplasm

increased tumor incidence ( J:264300 )

• at 16 months of age

increased lung adenoma incidence ( J:264300 )

cellular

aneuploidy ( J:264300 )

• in splenocytes at 5 months of age

respiratory system

increased lung adenoma incidence ( J:264300 )