Analysis Tools
mortality/aging
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• mutants die within 30 minutes of birth
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nervous system
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• at E13.5, apoptosis is increased in the dorsal root ganglia and trigeminal ganglia, but not in the brain
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• at E13.5, proliferation is increased in the brain, dorsal root ganglia, and trigeminal ganglia
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• at E18.5, mutant brains are visibly larger than controls
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• at E18.5, mutant brains weigh 27% more than controls and no signs of hydrocephalus are seen
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vision/eye
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• at E13.5 and E18.5, ectopic proliferating cells are seen in the interior of the lens and increased apoptosis is seen
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behavior/neurological
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• seen at E18.5
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muscle
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• at E18.5 skeletal muscle differentiation is impaired, abnormally large nuclei with inappropriate S-phase activity are present, and myotubes appear diffusely arranged
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hematopoietic system
| N |
• at E13.5 peripheral blood smears contain the normal mix of nucleated and enucleated erythrocytes
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liver/biliary system
| N |
• at E13.5, liver cellularity and level of apoptosis are normal
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cellular
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• at E13.5, apoptosis is increased in the dorsal root ganglia and trigeminal ganglia, but not in the brain
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• at E13.5, proliferation is increased in the brain, dorsal root ganglia, and trigeminal ganglia
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