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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Spag16tm2Jfs
targeted mutation 2, Jerome F Strauss III
MGI:3606979
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Spag16tm2Jfs/Spag16tm2Jfs involves: 129S6/SvEvTac MGI:3622100
ht2
 		Spag16tm2Jfs/Spag16+ involves: 129S6/SvEvTac MGI:3622099


Genotype
MGI:3622100
hm1
Allelic
Composition		 Spag16tm2Jfs/Spag16tm2Jfs
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spag16tm2Jfs mutation (0 available); any Spag16 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
teratozoospermia ( J:107006 )
• disorganization of the sperm axonemal structure is observed
• only a small number of null sperm are motile and showed progressive forward motility; the mean curvilinear velocity of mutant sperm is significantly lower in mutants compared to homozygotes
asthenozoospermia ( J:107006 )
• motility of sperm in mutants is defective

reproductive system
teratozoospermia ( J:107006 )
• disorganization of the sperm axonemal structure is observed
• only a small number of null sperm are motile and showed progressive forward motility; the mean curvilinear velocity of mutant sperm is significantly lower in mutants compared to homozygotes
asthenozoospermia ( J:107006 )
• motility of sperm in mutants is defective
small testis ( J:107006 )
• a general trend toward smaller testes in mutants is observed
male infertility ( J:107006 )
• homozygous males are infertile because no pregnancies are produce in 2 months of mating

endocrine/exocrine glands
small testis ( J:107006 )
• a general trend toward smaller testes in mutants is observed




Genotype
MGI:3622099
ht2
Allelic
Composition		 Spag16tm2Jfs/Spag16+
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spag16tm2Jfs mutation (0 available); any Spag16 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal spermatogenesis ( J:107006 )
• highly chimeric males have impaired spermatogenesis, with a loss of germ cells at the round spermatid stage




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory