About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Spag16tm2Jfs
targeted mutation 2, Jerome F Strauss III
MGI:3606979
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Spag16tm2Jfs/Spag16tm2Jfs involves: 129S6/SvEvTac MGI:3622100
ht2
 		Spag16tm2Jfs/Spag16+ involves: 129S6/SvEvTac MGI:3622099


Genotype
MGI:3622100
hm1
Allelic
Composition		 Spag16tm2Jfs/Spag16tm2Jfs
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spag16tm2Jfs mutation (0 available); any Spag16 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
teratozoospermia ( J:107006 )
• disorganization of the sperm axonemal structure is observed
• only a small number of null sperm are motile and showed progressive forward motility; the mean curvilinear velocity of mutant sperm is significantly lower in mutants compared to homozygotes
asthenozoospermia ( J:107006 )
• motility of sperm in mutants is defective

reproductive system
teratozoospermia ( J:107006 )
• disorganization of the sperm axonemal structure is observed
• only a small number of null sperm are motile and showed progressive forward motility; the mean curvilinear velocity of mutant sperm is significantly lower in mutants compared to homozygotes
asthenozoospermia ( J:107006 )
• motility of sperm in mutants is defective
small testis ( J:107006 )
• a general trend toward smaller testes in mutants is observed
male infertility ( J:107006 )
• homozygous males are infertile because no pregnancies are produce in 2 months of mating

endocrine/exocrine glands
small testis ( J:107006 )
• a general trend toward smaller testes in mutants is observed




Genotype
MGI:3622099
ht2
Allelic
Composition		 Spag16tm2Jfs/Spag16+
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spag16tm2Jfs mutation (0 available); any Spag16 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal spermatogenesis ( J:107006 )
• highly chimeric males have impaired spermatogenesis, with a loss of germ cells at the round spermatid stage




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/03/2024
MGI 6.24 		The Jackson Laboratory