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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Clip1tm1Gal
targeted mutation 1, Niels Galjart
MGI:3607145
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Clip1tm1Gal/Clip1tm1Gal involves: 129P2/OlaHsd MGI:3695564
hm2
 		Clip1tm1Gal/Clip1tm1Gal involves: 129P2/OlaHsd * C57BL/6 MGI:3608988


Genotype
MGI:3695564
hm1
Allelic
Composition		 Clip1tm1Gal/Clip1tm1Gal
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clip1tm1Gal mutation (0 available); any Clip1 mutation (83 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
cellular phenotype ( J:116121 )
N
• no obvious microtubule abnormalities in MEFs in a wound healing assay




Genotype
MGI:3608988
hm2
Allelic
Composition		 Clip1tm1Gal/Clip1tm1Gal
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clip1tm1Gal mutation (0 available); any Clip1 mutation (83 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
teratozoospermia ( J:102107 )
• all mutant sperm exhibit an abnormal morphology
• however, sperm numbers and motility are similar to wild-type
abnormal sperm flagellum morphology ( J:102107 )
• 20% of mutant sperm exhibit combined head and tail defects
abnormal sperm head morphology ( J:102107 )
• 100% of mutant sperm display severe head abnormalities
• 20% of mutant sperm exhibit combined head and tail defects
abnormal manchette morphology ( J:102107 )
• in step 8-9 spermatids developing manchettes have abnormal and ectopic microtubule formations
• however, the few cross-bridges between microtubules are similar to wild-type in size
reduced male fertility ( J:102107 )
• homozygous males produce almost no offspring

cellular
teratozoospermia ( J:102107 )
• all mutant sperm exhibit an abnormal morphology
• however, sperm numbers and motility are similar to wild-type
abnormal sperm flagellum morphology ( J:102107 )
• 20% of mutant sperm exhibit combined head and tail defects
abnormal sperm head morphology ( J:102107 )
• 100% of mutant sperm display severe head abnormalities
• 20% of mutant sperm exhibit combined head and tail defects
abnormal manchette morphology ( J:102107 )
• in step 8-9 spermatids developing manchettes have abnormal and ectopic microtubule formations
• however, the few cross-bridges between microtubules are similar to wild-type in size




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory