All Phenotypes Del(13)36H MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Del(13)36H
deletion, Chr 13, Harwell 36
MGI:3607783

Summary

13 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	sau/Del(13)36H Foxq1^sa/Foxq1⁺	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:3607793
cx2	Foxq1^sa/Foxq1⁺ Sox4^M91Ark/Del(13)36H	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:3819858
cx3	Foxq1^sa/Foxq1⁺ M1073b/Del(13)36H	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:5516034
cx4	M1185b/Del(13)36H Foxq1^sa/Foxq1⁺	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:5516037
cx5	M1616b/Del(13)36H Foxq1^sa/Foxq1⁺	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:5516038
cx6	M1645b/Del(13)36H Foxq1^sa/Foxq1⁺	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:5516039
cx7	M241b/Del(13)36H Foxq1^sa/Foxq1⁺	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:5516040
cx8	M369b/Del(13)36H Foxq1^sa/Foxq1⁺	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:5516041
cx9	M412b/Del(13)36H Foxq1^sa/Foxq1⁺	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:5516044
cx10	M54b/Del(13)36H Foxq1^sa/Foxq1⁺	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:5516045
cx11	M624b/Del(13)36H Foxq1^sa/Foxq1⁺	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:5516046
cx12	M876b/Del(13)36H Foxq1^sa/Foxq1⁺	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:5516047
cx13	Sox4^Igt4/Del(13)36H	involves: 101/H * C3H/HeH * C57BL/6	MGI:3819947

Allelic Composition	sau/Del(13)36H Foxq1^sa/Foxq1⁺
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13)36H mutation (0 available); any Del(13)36H mutation (0 available)
Foxq1^sa mutation (16 available); any Foxq1 mutation (29 available)
sau mutation (2 available); any sau mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:101156 )

• hemizygous progeny are born at less than one-third the expected Mendelian frequency, most dying by 16.5 days post coitum (16.5 dpc)

nervous system

holoprosencephaly ( J:101156 )

• hemizygous embyros examined at 9.5 dpc often exhibit midline forebrain defects and other aspects of holoprocencephaly

• some hemizygotes that survive to birth exhibit holoprosencephalic phenotypes of varying severity

vision/eye

abnormal eye development ( J:101156 )

• some hemizygous embryos and liveborn pups exhibit structural eye defects

cyclopia ( J:101156 )

Allelic Composition	Foxq1^sa/Foxq1⁺ Sox4^M91Ark/Del(13)36H
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13)36H mutation (0 available); any Del(13)36H mutation (0 available)
Foxq1^sa mutation (16 available); any Foxq1 mutation (29 available)
Sox4^M91Ark mutation (2 available); any Sox4 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:101156 )

• almost all mice die before birth, with a significant deviation from expected Mendelian frequencies first noted at E14.5

cardiovascular system

abnormal aortic arch morphology ( J:101156 )

• smaller than the pulmonary artery

abnormal cardiovascular development ( J:101156 )

• circulatory failure

abnormal heart morphology ( J:101156 )

abnormal heart development ( J:101156 )

• common atrioventricular junction

double outlet right ventricle ( J:101156 )

• the aorta and pulmonary artery both originate from the right ventricle

abnormal mitral valve morphology ( J:101156 )

• the mitral valve of E14.5 embryos is dysplastic

ostium primum atrial septal defect ( J:101156 )

• a primum atrial septal defect is seen at the ventral margin of the primary atrial septum in E14.5 embryos

ventricular septal defect ( J:101156 )

• a large ventricular septum defect connects the left and right ventricles

renal/urinary system

abnormal kidney development ( J:101156 )

• kidneys of E14.5 embryos are hypoplastic and occasionally positioned abnormally

renal hypoplasia ( J:101156 )

nervous system

holoprosencephaly ( J:101156 )

Allelic Composition	Foxq1^sa/Foxq1⁺ M1073b/Del(13)36H
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13)36H mutation (0 available); any Del(13)36H mutation (0 available)
Foxq1^sa mutation (16 available); any Foxq1 mutation (29 available)
M1073b mutation (2 available); any M1073b mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality ( J:101156 )

• lethality occurs in the second half of gestation

craniofacial

abnormal craniofacial morphology ( J:101156 )

abnormal tooth morphology ( J:101156 )

absent mandible ( J:101156 )

• microagnathia/agnathia

micrognathia ( J:101156 )

• microagnathia/agnathia

abnormal palate morphology ( J:101156 )

nervous system

holoprosencephaly ( J:101156 )

abnormal forebrain morphology ( J:101156 )

hearing/vestibular/ear

abnormal ear morphology ( J:101156 )

vision/eye

abnormal eye morphology ( J:101156 )

digestive/alimentary system

abnormal palate morphology ( J:101156 )

skeleton

abnormal tooth morphology ( J:101156 )

absent mandible ( J:101156 )

• microagnathia/agnathia

micrognathia ( J:101156 )

• microagnathia/agnathia

growth/size/body

abnormal tooth morphology ( J:101156 )

abnormal palate morphology ( J:101156 )

microcephaly ( J:101156 )

Allelic Composition	M1185b/Del(13)36H Foxq1^sa/Foxq1⁺
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13)36H mutation (0 available); any Del(13)36H mutation (0 available)
Foxq1^sa mutation (16 available); any Foxq1 mutation (29 available)
M1185b mutation (2 available); any M1185b mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, incomplete penetrance ( J:101156 )

• lethality occurs in the second half of gestation

cardiovascular system

abnormal heart morphology ( J:101156 )

Allelic Composition	M1616b/Del(13)36H Foxq1^sa/Foxq1⁺
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13)36H mutation (0 available); any Del(13)36H mutation (0 available)
Foxq1^sa mutation (16 available); any Foxq1 mutation (29 available)
M1616b mutation (2 available); any M1616b mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, incomplete penetrance ( J:101156 )

• lethality occurs in the second half of gestation

embryo

failure of chorioallantoic fusion ( J:101156 )

Allelic Composition	M1645b/Del(13)36H Foxq1^sa/Foxq1⁺
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13)36H mutation (0 available); any Del(13)36H mutation (0 available)
Foxq1^sa mutation (16 available); any Foxq1 mutation (29 available)
M1645b mutation (2 available); any M1645b mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, incomplete penetrance ( J:101156 )

• lethality occurs in the second half of gestation

Allelic Composition	M241b/Del(13)36H Foxq1^sa/Foxq1⁺
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13)36H mutation (0 available); any Del(13)36H mutation (0 available)
Foxq1^sa mutation (16 available); any Foxq1 mutation (29 available)
M241b mutation (2 available); any M241b mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, incomplete penetrance ( J:101156 )

• lethality occurs in the second half of gestation

nervous system

holoprosencephaly ( J:101156 )

abnormal forebrain morphology ( J:101156 )

vision/eye

anophthalmia ( J:101156 )

• without micrognathia

Allelic Composition	M369b/Del(13)36H Foxq1^sa/Foxq1⁺
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13)36H mutation (0 available); any Del(13)36H mutation (0 available)
Foxq1^sa mutation (16 available); any Foxq1 mutation (29 available)
M369b mutation (2 available); any M369b mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality ( J:101156 )

• lethality occurs in the second half of gestation

nervous system

exencephaly ( J:101156 )

Allelic Composition	M412b/Del(13)36H Foxq1^sa/Foxq1⁺
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13)36H mutation (0 available); any Del(13)36H mutation (0 available)
Foxq1^sa mutation (16 available); any Foxq1 mutation (29 available)
M412b mutation (2 available); any M412b mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality ( J:101156 )

• lethality occurs in the second half of gestation

craniofacial

abnormal craniofacial morphology ( J:101156 )

abnormal tooth morphology ( J:101156 )

absent mandible ( J:101156 )

• microagnathia/agnathia

micrognathia ( J:101156 )

• microagnathia/agnathia

abnormal palate morphology ( J:101156 )

nervous system

holoprosencephaly ( J:101156 )

abnormal forebrain morphology ( J:101156 )

abnormal lateral ventricle morphology ( J:101156 )

• hypoplastic with no development of the interhemispheric fissure

abnormal hindbrain morphology ( J:101156 )

hearing/vestibular/ear

abnormal ear morphology ( J:101156 )

vision/eye

abnormal eye morphology ( J:101156 )

digestive/alimentary system

abnormal palate morphology ( J:101156 )

skeleton

abnormal tooth morphology ( J:101156 )

absent mandible ( J:101156 )

• microagnathia/agnathia

micrognathia ( J:101156 )

• microagnathia/agnathia

growth/size/body

abnormal tooth morphology ( J:101156 )

abnormal palate morphology ( J:101156 )

microcephaly ( J:101156 )

Allelic Composition	M54b/Del(13)36H Foxq1^sa/Foxq1⁺
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13)36H mutation (0 available); any Del(13)36H mutation (0 available)
Foxq1^sa mutation (16 available); any Foxq1 mutation (29 available)
M54b mutation (2 available); any M54b mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality ( J:101156 )

• lethality occurs in the second half of gestation

craniofacial

abnormal craniofacial morphology ( J:101156 )

abnormal tooth morphology ( J:101156 )

absent mandible ( J:101156 )

• microagnathia/agnathia

micrognathia ( J:101156 )

• microagnathia/agnathia

abnormal palate morphology ( J:101156 )

nervous system

holoprosencephaly ( J:101156 )

abnormal forebrain morphology ( J:101156 )

abnormal lateral ventricle morphology ( J:101156 )

• hypoplastic with no development of the interhemispheric fissure

hearing/vestibular/ear

abnormal ear morphology ( J:101156 )

• absence of ear pinnae at E15.5

vision/eye

anophthalmia ( J:101156 )

digestive/alimentary system

abnormal palate morphology ( J:101156 )

skeleton

abnormal tooth morphology ( J:101156 )

absent mandible ( J:101156 )

• microagnathia/agnathia

micrognathia ( J:101156 )

• microagnathia/agnathia

growth/size/body

abnormal tooth morphology ( J:101156 )

abnormal palate morphology ( J:101156 )

microcephaly ( J:101156 )

Allelic Composition	M624b/Del(13)36H Foxq1^sa/Foxq1⁺
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13)36H mutation (0 available); any Del(13)36H mutation (0 available)
Foxq1^sa mutation (16 available); any Foxq1 mutation (29 available)
M624b mutation (2 available); any M624b mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality ( J:101156 )

• lethality occurs in the second half of gestation

nervous system

holoprosencephaly ( J:101156 )

abnormal forebrain morphology ( J:101156 )

vision/eye

abnormal eye morphology ( J:101156 )

• a single, ventrally displaced eye

Allelic Composition	M876b/Del(13)36H Foxq1^sa/Foxq1⁺
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13)36H mutation (0 available); any Del(13)36H mutation (0 available)
Foxq1^sa mutation (16 available); any Foxq1 mutation (29 available)
M876b mutation (2 available); any M876b mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality ( J:101156 )

• lethality occurs in the second half of gestation

Allelic Composition	Sox4^Igt4/Del(13)36H
Genetic Background	involves: 101/H * C3H/HeH * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13)36H mutation (0 available); any Del(13)36H mutation (0 available)
Sox4^Igt4 mutation (1 available); any Sox4 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:141688 )

• mice die in utero around E14.5

cardiovascular system

interrupted aortic arch ( J:141688 )

• hypoplastic or interrupted aortic arches are observed in E14.5 fetuses

double outlet right ventricle ( J:141688 )

• the aorta and pulmonary artery both originate from the right ventricle

abnormal atrioventricular valve morphology ( J:141688 )

• the atrioventricular valves of E14.5 embryos are dysplastic

subarterial ventricular septal defect ( J:141688 )

• a large outlet ventricular septum defect connects the left and right ventricles

craniofacial

cleft palate ( J:141688 )

• 60% of E14.5 embryos have cleft palate

digestive/alimentary system

cleft palate ( J:141688 )

• 60% of E14.5 embryos have cleft palate

hematopoietic system

thymus hypoplasia ( J:141688 )

• bilateral hypoplasia of the thymus is noted in one case

homeostasis/metabolism

extremity edema ( J:141688 )

• severe edema is observed in the extremities of the E14.5 fetus

immune system

thymus hypoplasia ( J:141688 )

• bilateral hypoplasia of the thymus is noted in one case

renal/urinary system

renal hypoplasia ( J:141688 )

• bilateral renal hypoplasia is noted in one case

endocrine/exocrine glands

thymus hypoplasia ( J:141688 )

• bilateral hypoplasia of the thymus is noted in one case

growth/size/body

cleft palate ( J:141688 )

• 60% of E14.5 embryos have cleft palate

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