Phenotypes associated with this allele

• Allele Symbol: Ret^tm5(RET)Vpa
• Allele Name: targeted mutation 5, Vassilis Pachnis
• Allele ID: MGI:3607931
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ret^tm5(RET)Vpa/Ret^tm5(RET)Vpa	either: 129S1/Sv-Ret^tm5(RET)Vpa or (involves: 129S1/Sv * C57BL/6J)	MGI:3609199

Genotype
MGI:3609199

hm1

• Allelic Composition: Ret^tm5(RET)Vpa/Ret^tm5(RET)Vpa
• Genetic Background: either: 129S1/Sv-Ret^tm5(RET)Vpa or (involves: 129S1/Sv * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal enteric ganglia morphology ( J:102170 )

• enteric ganglia are absent from the distal portion of the colon

renal/urinary system

kidney cyst ( J:102170 )

• cysts are seen in many homozygous kidneys

decreased renal glomerulus number ( J:102170 )

• fewer glomeruli are seen in many homozygous kidneys

small kidney ( J:102170 )

• kidneys are reduced in size compared to wild-type mice but larger than those in Ret^tm2(RET)Vpa homozygotes

growth/size/body

kidney cyst ( J:102170 )

• cysts are seen in many homozygous kidneys