About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pik3r1tm1Lca
targeted mutation 1, Lewis C Cantley
MGI:3607981
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Krastm4Tyj/Kras+
Pik3r1tm1Lca/Pik3r1tm1Lca
Pik3r2tm1Lca/Pik3r2tm1Lca 		involves: 129S4/SvJae * 129S6/SvEvTac MGI:3834443
cn2
 		Krastm4Tyj/Kras+
Pik3r1tm1Lca/Pik3r1+
Pik3r2tm1Lca/Pik3r2tm1Lca 		involves: 129S4/SvJae * 129S6/SvEvTac MGI:3834445
cn3
 		Pik3r1tm1Lca/Pik3r1tm1Lca
Tg(Ckmm-cre)5Khn/0 		involves: 129S6/SvEvTac * C57BL/6 * FVB MGI:3609011
cn4
 		Pik3r1tm1Lca/Pik3r1tm1Lca
Pik3r2tm1Lca/Pik3r2tm1Lca
Tg(Ckmm-cre)5Khn/0 		involves: 129S6/SvEvTac * C57BL/6 * FVB MGI:3609012
cn5
 		Pik3r1tm1Lca/Pik3r1tm1Lca
Tg(OPN1LW-cre)4Yzl/0 		involves: 129S6/SvEvTac * FVB/N MGI:6382536


Genotype
MGI:3834443
cn1
Allelic
Composition		 Krastm4Tyj/Kras+
Pik3r1tm1Lca/Pik3r1tm1Lca
Pik3r2tm1Lca/Pik3r2tm1Lca
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Pik3r1tm1Lca mutation (1 available); any Pik3r1 mutation (56 available)
Pik3r2tm1Lca mutation (1 available); any Pik3r2 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased lung tumor incidence ( J:142254 )
• following administration of inhaled adenovirus cre, mice develop fewer lung tumors than in Krastm4Tyj/Kras+ Pik3r2tm1Lca/Pik3r2tm1Lca or Krastm4Tyj/Kras+ Pik3r2tm1Lca/Pik3r2tm1Lca Pik3r1tm1Lca/Pik3r1+ mice

respiratory system
decreased lung tumor incidence ( J:142254 )
• following administration of inhaled adenovirus cre, mice develop fewer lung tumors than in Krastm4Tyj/Kras+ Pik3r2tm1Lca/Pik3r2tm1Lca or Krastm4Tyj/Kras+ Pik3r2tm1Lca/Pik3r2tm1Lca Pik3r1tm1Lca/Pik3r1+ mice




Genotype
MGI:3834445
cn2
Allelic
Composition		 Krastm4Tyj/Kras+
Pik3r1tm1Lca/Pik3r1+
Pik3r2tm1Lca/Pik3r2tm1Lca
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Pik3r1tm1Lca mutation (1 available); any Pik3r1 mutation (56 available)
Pik3r2tm1Lca mutation (1 available); any Pik3r2 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased lung tumor incidence ( J:142254 )
• following administration of inhaled adenovirus cre

respiratory system
increased lung tumor incidence ( J:142254 )
• following administration of inhaled adenovirus cre




Genotype
MGI:3609011
cn3
Allelic
Composition		 Pik3r1tm1Lca/Pik3r1tm1Lca
Tg(Ckmm-cre)5Khn/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3r1tm1Lca mutation (1 available); any Pik3r1 mutation (56 available)
Tg(Ckmm-cre)5Khn mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:102176 )
• mutants are viable and fertile, with no gross abnormalities and normal muscle morphology




Genotype
MGI:3609012
cn4
Allelic
Composition		 Pik3r1tm1Lca/Pik3r1tm1Lca
Pik3r2tm1Lca/Pik3r2tm1Lca
Tg(Ckmm-cre)5Khn/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3r1tm1Lca mutation (1 available); any Pik3r1 mutation (56 available)
Pik3r2tm1Lca mutation (1 available); any Pik3r2 mutation (38 available)
Tg(Ckmm-cre)5Khn mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased myocardial fiber size ( J:102176 )
• most cardiomyocytes are reduced in size
decreased heart weight ( J:102176 )
• heart size normalized to body weight or tibia length is about 20% smaller than in wild-type mice; however the structure of the heart is normal with no obvious signs of fibrosis or tissue damage
• the increase in heart size in response to exercise is decreased compared to wild-type mice

muscle
decreased myocardial fiber size ( J:102176 )
• most cardiomyocytes are reduced in size




Genotype
MGI:6382536
cn5
Allelic
Composition		 Pik3r1tm1Lca/Pik3r1tm1Lca
Tg(OPN1LW-cre)4Yzl/0
Genetic
Background		 involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3r1tm1Lca mutation (1 available); any Pik3r1 mutation (56 available)
Tg(OPN1LW-cre)4Yzl mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal retina cone cell morphology ( J:232389 )
• progressive disorganization of synaptic ultrastructure is seen in the terminals of surviving cones at 6 and 12 months of age but not at 1 month
retina cone cell degeneration ( J:232389 )
• retinas show patchy regions devoid of cones by 6 months and cone photoreceptor loss is further exacerbated by 12 months of age
• the inferior meridian region of the retinas shows greater cone loss than the superior region at 6 months but by 12 months, similar loss of cones is seen in both regions
• however, the overall morphology and structural integrity of the retina are similar to wild-type mice at 1, 6, and 12 months of age
decreased b-wave amplitude ( J:232389 )
• scotopic b-wave amplitudes are lower at 6 and 12 months of age compared with control floxed mice but are not different from control cre-only expressing mice
• photopic ERG b-wave amplitudes are decreased at 6 months, but not 1 month of age, and decrease progressively to 12 months
• however, scotopic ERG recordings of rod photoreceptors (scotopic a-wave) are normal at 1, 6, and 12 months of age

nervous system
abnormal retina cone cell morphology ( J:232389 )
• progressive disorganization of synaptic ultrastructure is seen in the terminals of surviving cones at 6 and 12 months of age but not at 1 month
retina cone cell degeneration ( J:232389 )
• retinas show patchy regions devoid of cones by 6 months and cone photoreceptor loss is further exacerbated by 12 months of age
• the inferior meridian region of the retinas shows greater cone loss than the superior region at 6 months but by 12 months, similar loss of cones is seen in both regions
• however, the overall morphology and structural integrity of the retina are similar to wild-type mice at 1, 6, and 12 months of age
abnormal synapse morphology ( J:232389 )
• progressive disorganization of synaptic ultrastructure is seen in the terminals of surviving cones at 6 and 12 months of age but not at 1 month
abnormal ribbon synapse morphology ( J:232389 )
• cone terminals in the retina ribbon synaptic complexes are reduced, flat contacts are sometimes located adjacent to synaptic ribbons, and interactions with postsynaptic processes appear disorganized




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory