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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pik3r1tm1Lca
targeted mutation 1, Lewis C Cantley
MGI:3607981
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Krastm4Tyj/Kras+
Pik3r1tm1Lca/Pik3r1tm1Lca
Pik3r2tm1Lca/Pik3r2tm1Lca 		involves: 129S4/SvJae * 129S6/SvEvTac MGI:3834443
cn2
 		Krastm4Tyj/Kras+
Pik3r1tm1Lca/Pik3r1+
Pik3r2tm1Lca/Pik3r2tm1Lca 		involves: 129S4/SvJae * 129S6/SvEvTac MGI:3834445
cn3
 		Pik3r1tm1Lca/Pik3r1tm1Lca
Tg(Ckmm-cre)5Khn/0 		involves: 129S6/SvEvTac * C57BL/6 * FVB MGI:3609011
cn4
 		Pik3r1tm1Lca/Pik3r1tm1Lca
Pik3r2tm1Lca/Pik3r2tm1Lca
Tg(Ckmm-cre)5Khn/0 		involves: 129S6/SvEvTac * C57BL/6 * FVB MGI:3609012
cn5
 		Pik3r1tm1Lca/Pik3r1tm1Lca
Tg(OPN1LW-cre)4Yzl/0 		involves: 129S6/SvEvTac * FVB/N MGI:6382536


Genotype
MGI:3834443
cn1
Allelic
Composition		 Krastm4Tyj/Kras+
Pik3r1tm1Lca/Pik3r1tm1Lca
Pik3r2tm1Lca/Pik3r2tm1Lca
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Pik3r1tm1Lca mutation (1 available); any Pik3r1 mutation (56 available)
Pik3r2tm1Lca mutation (1 available); any Pik3r2 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased lung tumor incidence ( J:142254 )
• following administration of inhaled adenovirus cre, mice develop fewer lung tumors than in Krastm4Tyj/Kras+ Pik3r2tm1Lca/Pik3r2tm1Lca or Krastm4Tyj/Kras+ Pik3r2tm1Lca/Pik3r2tm1Lca Pik3r1tm1Lca/Pik3r1+ mice

respiratory system
decreased lung tumor incidence ( J:142254 )
• following administration of inhaled adenovirus cre, mice develop fewer lung tumors than in Krastm4Tyj/Kras+ Pik3r2tm1Lca/Pik3r2tm1Lca or Krastm4Tyj/Kras+ Pik3r2tm1Lca/Pik3r2tm1Lca Pik3r1tm1Lca/Pik3r1+ mice




Genotype
MGI:3834445
cn2
Allelic
Composition		 Krastm4Tyj/Kras+
Pik3r1tm1Lca/Pik3r1+
Pik3r2tm1Lca/Pik3r2tm1Lca
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Pik3r1tm1Lca mutation (1 available); any Pik3r1 mutation (56 available)
Pik3r2tm1Lca mutation (1 available); any Pik3r2 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased lung tumor incidence ( J:142254 )
• following administration of inhaled adenovirus cre

respiratory system
increased lung tumor incidence ( J:142254 )
• following administration of inhaled adenovirus cre




Genotype
MGI:3609011
cn3
Allelic
Composition		 Pik3r1tm1Lca/Pik3r1tm1Lca
Tg(Ckmm-cre)5Khn/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3r1tm1Lca mutation (1 available); any Pik3r1 mutation (56 available)
Tg(Ckmm-cre)5Khn mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:102176 )
• mutants are viable and fertile, with no gross abnormalities and normal muscle morphology




Genotype
MGI:3609012
cn4
Allelic
Composition		 Pik3r1tm1Lca/Pik3r1tm1Lca
Pik3r2tm1Lca/Pik3r2tm1Lca
Tg(Ckmm-cre)5Khn/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3r1tm1Lca mutation (1 available); any Pik3r1 mutation (56 available)
Pik3r2tm1Lca mutation (1 available); any Pik3r2 mutation (38 available)
Tg(Ckmm-cre)5Khn mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased myocardial fiber size ( J:102176 )
• most cardiomyocytes are reduced in size
decreased heart weight ( J:102176 )
• heart size normalized to body weight or tibia length is about 20% smaller than in wild-type mice; however the structure of the heart is normal with no obvious signs of fibrosis or tissue damage
• the increase in heart size in response to exercise is decreased compared to wild-type mice

muscle
decreased myocardial fiber size ( J:102176 )
• most cardiomyocytes are reduced in size




Genotype
MGI:6382536
cn5
Allelic
Composition		 Pik3r1tm1Lca/Pik3r1tm1Lca
Tg(OPN1LW-cre)4Yzl/0
Genetic
Background		 involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3r1tm1Lca mutation (1 available); any Pik3r1 mutation (56 available)
Tg(OPN1LW-cre)4Yzl mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal retina cone cell morphology ( J:232389 )
• progressive disorganization of synaptic ultrastructure is seen in the terminals of surviving cones at 6 and 12 months of age but not at 1 month
retina cone cell degeneration ( J:232389 )
• retinas show patchy regions devoid of cones by 6 months and cone photoreceptor loss is further exacerbated by 12 months of age
• the inferior meridian region of the retinas shows greater cone loss than the superior region at 6 months but by 12 months, similar loss of cones is seen in both regions
• however, the overall morphology and structural integrity of the retina are similar to wild-type mice at 1, 6, and 12 months of age
decreased b-wave amplitude ( J:232389 )
• scotopic b-wave amplitudes are lower at 6 and 12 months of age compared with control floxed mice but are not different from control cre-only expressing mice
• photopic ERG b-wave amplitudes are decreased at 6 months, but not 1 month of age, and decrease progressively to 12 months
• however, scotopic ERG recordings of rod photoreceptors (scotopic a-wave) are normal at 1, 6, and 12 months of age

nervous system
abnormal retina cone cell morphology ( J:232389 )
• progressive disorganization of synaptic ultrastructure is seen in the terminals of surviving cones at 6 and 12 months of age but not at 1 month
retina cone cell degeneration ( J:232389 )
• retinas show patchy regions devoid of cones by 6 months and cone photoreceptor loss is further exacerbated by 12 months of age
• the inferior meridian region of the retinas shows greater cone loss than the superior region at 6 months but by 12 months, similar loss of cones is seen in both regions
• however, the overall morphology and structural integrity of the retina are similar to wild-type mice at 1, 6, and 12 months of age
abnormal synapse morphology ( J:232389 )
• progressive disorganization of synaptic ultrastructure is seen in the terminals of surviving cones at 6 and 12 months of age but not at 1 month
abnormal ribbon synapse morphology ( J:232389 )
• cone terminals in the retina ribbon synaptic complexes are reduced, flat contacts are sometimes located adjacent to synaptic ribbons, and interactions with postsynaptic processes appear disorganized




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory