All Phenotypes Mib1<tm1Art> MGI Mouse

embryonic lethality during organogenesis, complete penetrance ( J:102528 )

• at E10.5, homozygous embryos are moribund, although their hearts still beat weakly; they die around this time

premature neuronal precursor differentiation ( J:102528 )

• neuroepithelial cells in mutant embryos differentiate prematurely, en masse, by E9.5, when they show no evidence of lateral inhibition and differentiation within the tissue is no longer polarized towards the pial surface

abnormal embryonic neuroepithelium morphology ( J:102528 )

• at E10.5, the neuroepithelium of mutant embryos is necrotic

abnormal embryonic neuroepithelial layer differentiation ( J:102528 )

• although the heads of homozygous embryos appear grossly normal at E9.5, histopathological examination reveals neuroepithelial defects, including hypocellularity and in many cases, failure of tissue integrity

kinked neural tube ( J:102528 )

• at E8.5, homozygous embryos have a kinked neural tube

abnormal vitelline vasculature morphology ( J:102528 )

• dissection of E9.5 homozygotes reveals vascularization defects of the yolk sac

absent second pharyngeal arch ( J:102528 )

• the second branchial arch has failed to develop in homozygous embryos by E9.5

abnormal rostral-caudal axis patterning ( J:102528 )

• at E9.5, the body axis of mutant embryos is foreshortened

abnormal embryonic neuroepithelium morphology ( J:102528 )

• at E10.5, the neuroepithelium of mutant embryos is necrotic

abnormal embryonic neuroepithelial layer differentiation ( J:102528 )

• although the heads of homozygous embryos appear grossly normal at E9.5, histopathological examination reveals neuroepithelial defects, including hypocellularity and in many cases, failure of tissue integrity

kinked neural tube ( J:102528 )

• at E8.5, homozygous embryos have a kinked neural tube

abnormal somite shape ( J:102528 )

• if somites are present in E8.5 homozygotes, they are irregular with poorly defined edges

failure of somite differentiation ( J:102528 )

• somites are few or absent in E8.5 mutant embryos

incomplete somite formation ( J:102528 )

• somites are few or absent inE8.5 mutant embryos

failure of chorioallantoic fusion ( J:102528 )

• at E10.5, the allantois of mutant embryos has a rounded appearance, indicating failure to develop a plancental connection

abnormal blood vessel morphology ( J:102528 )

• dissection of E9.5 mutant embryos reveals vascularization defects of the embryo proper

abnormal vitelline vasculature morphology ( J:102528 )

• dissection of E9.5 homozygotes reveals vascularization defects of the yolk sac

abnormal heart looping ( J:102528 )

• at E9.5, the hearts of homozygous embryos are poorly folded

pericardial edema ( J:102528 )

• E9.5 mutant embryos exhibit edema of the pericardium