All Phenotypes Cx3cr1<tm1Zm> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cx3cr1^tm1Zm/Cx3cr1^tm1Zm	C.129-Cx3cr1^tm1Zm	MGI:3814728
hm2	Cx3cr1^tm1Zm/Cx3cr1^tm1Zm	involves: 129 * C57BL/6	MGI:3814729
hm3	Cx3cr1^tm1Zm/Cx3cr1^tm1Zm	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3618276
cx4	Apoe^tm1Unc/Apoe^tm1Unc Cx3cr1^tm1Zm/Cx3cr1^tm1Zm	B6.129-Apoe^tm1Unc Cx3cr1^tm1Zm	MGI:3618277
cx5	Apoe^tm1Unc/Apoe^tm1Unc Cx3cr1^tm1Zm/Cx3cr1⁺	B6.129-Apoe^tm1Unc Cx3cr1^tm1Zm	MGI:3618279
cx6	Ccl2^tm1Rol/Ccl2^tm1Rol Cx3cr1^tm1Zm/Cx3cr1^tm1Zm	involves: 129 * 129S4/SvJae	MGI:3814819

Allelic Composition	Cx3cr1^tm1Zm/Cx3cr1^tm1Zm
Genetic Background	C.129-Cx3cr1^tm1Zm

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Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cx3cr1^tm1Zm mutation (1 available); any Cx3cr1 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal retina morphology ( J:127548 )

• subretinal microglial cells accumulate with age in the retina unlike in wild-type mice

• however, dark raised mice exhibit reduced numbers of subretinal microglial cells in the retina

abnormal retina photoreceptor layer morphology ( J:127548 )

• however, dark raised mice do not exhibit thinning or degeneration

• the retinal photoreceptor layer is thin at 2 months and degenerated at 4 months of age

retina degeneration ( J:127548 )

• mice exhibit degeneration of the outer retina

• however, dark raised mice do not exhibit degeneration

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
age related macular degeneration 12		DOID:0110024	OMIM:613784	J:127548

Allelic Composition	Cx3cr1^tm1Zm/Cx3cr1^tm1Zm
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cx3cr1^tm1Zm mutation (1 available); any Cx3cr1 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

choroidal neovascularization ( J:127548 )

• following laser injury, choroid neovascularization is twice as much as in similarly treated wild-type mice

abnormal retina morphology ( J:127548 )

• subretinal microglial cells accumulate with age in the retina unlike in wild-type mice

thin retina outer nuclear layer ( J:127548 )

• at 12 months, mice exhibit a 30% reduction in the thickness of the retinal outer nuclear layer compared to in wild-type mice

abnormal retina photoreceptor layer morphology ( J:127548 )

• at 18 months, the thickness of the retinal photoreceptor cell layer is reduced to 40% of wild-type

• following laser injury, mice exhibit increased degeneration compared to untreated homozygotes or similarly treated wild-type mice

• however, mice do not exhibit increased degeneration following laser injuries at distances of 300 and 400 um from laser impact

retina degeneration ( J:127548 )

• at 18 months

retina deposits ( J:127548 )

• mice exhibit an accumulation of yellow, lipid-bloated subretinal microglial cells in the deep layer of the retina with age that is not observed in wild-type mice

cardiovascular system

choroidal neovascularization ( J:127548 )

• following laser injury, choroid neovascularization is twice as much as in similarly treated wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
age related macular degeneration 12		DOID:0110024	OMIM:613784	J:127548

Allelic Composition	Cx3cr1^tm1Zm/Cx3cr1^tm1Zm
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cx3cr1^tm1Zm mutation (1 available); any Cx3cr1 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal splenocyte physiology ( J:103047 )

• absent splenocyte chemotaxis in response to CX3CL1; however induction of T cell cytokine production by concanavalin A is similar to wild-type

immune system

abnormal splenocyte physiology ( J:103047 )

• absent splenocyte chemotaxis in response to CX3CL1; however induction of T cell cytokine production by concanavalin A is similar to wild-type

Allelic Composition	Apoe^tm1Unc/Apoe^tm1Unc Cx3cr1^tm1Zm/Cx3cr1^tm1Zm
Genetic Background	B6.129-Apoe^tm1Unc Cx3cr1^tm1Zm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Unc mutation (33 available); any Apoe mutation (158 available)
Cx3cr1^tm1Zm mutation (1 available); any Cx3cr1 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased susceptibility to atherosclerosis ( J:103047 )

• lesion area in the aorta and aortic sinus is decreased by about 50% compared to mice homozygous for the Apoe allele only; however the accumulation of smooth muscle cells and collagen within the plaque is similar to wild-type

• a 50% reduction is seen in the aortic sinus area containing monocyte-macrophage markers

Allelic Composition	Apoe^tm1Unc/Apoe^tm1Unc Cx3cr1^tm1Zm/Cx3cr1⁺
Genetic Background	B6.129-Apoe^tm1Unc Cx3cr1^tm1Zm

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased susceptibility to atherosclerosis ( J:103047 )

• lesion area in the thoracic aorta is decreased by about 50% compared to mice homozygous for the Apoe allele only

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

choroidal neovascularization ( J:126935 )

• beginning as early as 12 weeks of age,15% of mice exhibit neovascularization of the choroid unlike in wild-type mice

• choroidal neovascular vessels that penetrate Bruch membrane and enter the outer retinal layers are surrounded by hyperplastic retinal pigmented epithelium cells or atrophic retinal pigmented epithelium areas

abnormal retina morphology ( J:126935 )

• microglial infiltrates are observed in retinal lesions

disorganized photoreceptor outer segment ( J:126935 )

retina photoreceptor degeneration ( J:126935 )

• severity increases with age

abnormal retina pigment epithelium morphology ( J:126935 )

• unlike in wild-type mice, vacuolation of the retinal pigmented epithelium (RPE) is observed

• mice exhibit a reduction in melanosomes and an increase in lipofuscin in the RPE unlike in wild-type mice

abnormal retina pigmentation ( J:126935 )

• unlike in wild-type mice, local hypopigmentation of the retina is observed

retina pigment epithelium atrophy ( J:126935 )

• in some areas with severity increasing with age

retina pigment epithelium hyperplasia ( J:126935 )

• in some areas

retina deposits ( J:126935 )

• by 6 to 9 weeks, mice exhibit drusen-like lesions with heterogeneous, round or domed-shaped, soft-bordered yellowish deposits within the subretina not observed in wild-type mice

• retinal depositions enlarge or flatten and become confluent with age

abnormal Bruch membrane morphology ( J:126935 )

• beginning at 8 weeks of age, mice exhibit focal thickening in the Bruch membrane compared to wild-type mice

reproductive system

decreased litter size ( J:126935 )

• average litter size is half of wild-type

nervous system

disorganized photoreceptor outer segment ( J:126935 )

retina photoreceptor degeneration ( J:126935 )

• severity increases with age

pigmentation

variable depigmentation ( J:126935 )

• 20% of mice exhibit patchy skin depigmentation on the face and upper extremities

abnormal retina pigment epithelium morphology ( J:126935 )

• unlike in wild-type mice, vacuolation of the retinal pigmented epithelium (RPE) is observed

• mice exhibit a reduction in melanosomes and an increase in lipofuscin in the RPE unlike in wild-type mice

abnormal retina pigmentation ( J:126935 )

• unlike in wild-type mice, local hypopigmentation of the retina is observed

retina pigment epithelium atrophy ( J:126935 )

• in some areas with severity increasing with age

retina pigment epithelium hyperplasia ( J:126935 )

• in some areas

cardiovascular system

choroidal neovascularization ( J:126935 )

• beginning as early as 12 weeks of age,15% of mice exhibit neovascularization of the choroid unlike in wild-type mice

integument

variable depigmentation ( J:126935 )

• 20% of mice exhibit patchy skin depigmentation on the face and upper extremities

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
age related macular degeneration		DOID:10871	OMIM:PS603075	J:126935

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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