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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gadd45btm1Daa
targeted mutation 1, Dan A Liebermann
MGI:3608798
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gadd45btm1Daa/Gadd45btm1Daa involves: 129X1/SvJ * C57BL/6 MGI:3618358
cx2
 		Gadd45atm1Ajf/Gadd45atm1Ajf
Gadd45btm1Daa/Gadd45btm1Daa
Gadd45gtm1Mhol/Gadd45gtm1Mhol 		either: (involves: 129X1/SvJ) or (involves: 129P2/OlaHsd * 129X1/SvJ) MGI:3653937


Genotype
MGI:3618358
hm1
Allelic
Composition		 Gadd45btm1Daa/Gadd45btm1Daa
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gadd45btm1Daa mutation (1 available); any Gadd45b mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal bone marrow cell morphology/development ( J:102680 )
• increased apoptosis induced by UV, daunorubicin, or VP-16 is seen in bone marrow cells
• after UV chemotherapy or treatment with daunorubicin, or VP-16 homozygous bone marrow cells yield 3.7-fold or 8-16-fold, respectively, fewer IL-3 stimulated colonies compared to wild-type cells
• following treatment with UV or VP-16, but not daunorubicin, homozygous bone marrow cells fail to arrest at G2/M unlike wild-type cells




Genotype
MGI:3653937
cx2
Allelic
Composition		 Gadd45atm1Ajf/Gadd45atm1Ajf
Gadd45btm1Daa/Gadd45btm1Daa
Gadd45gtm1Mhol/Gadd45gtm1Mhol
Genetic
Background		 either: (involves: 129X1/SvJ) or (involves: 129P2/OlaHsd * 129X1/SvJ)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gadd45atm1Ajf mutation (2 available); any Gadd45a mutation (15 available)
Gadd45btm1Daa mutation (1 available); any Gadd45b mutation (12 available)
Gadd45gtm1Mhol mutation (0 available); any Gadd45g mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased cell proliferation ( J:110650 )
• proliferation in the outer medullas of triple knockouts




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory