homeostasis/metabolism
• plasma angiotensinogen levels are 20-30% of those in wild-type even though transgene expression rescues the Agt mutant phenotype and mutants are normotensive
|
Allele Symbol Allele Name Allele ID |
Tg(Fabp4-Agt)2Mte transgene insertion 2, Michele Teboul MGI:3608886 |
||||||||||||
Summary |
2 genotypes
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• plasma angiotensinogen levels are 20-30% of those in wild-type even though transgene expression rescues the Agt mutant phenotype and mutants are normotensive
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• higher total fat mass, epididymal fat pad weight, and adiposity index than in wild-type
|
• adipocyte hypoplasia
|
• increase in cell diameter and weight
|
• increase in epididymal fat pad weight
|
• significantly greater body weight than wild-type
|
• plasma angiotensinogen levels are increased (from 22 to 44%) compared to wild-type
|
• lower plasma renin activity
|
• locomotor activity in the daytime is slightly lower than in wild-type
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 08/21/2024 MGI 6.24 |
![]() |
|