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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ric8atm1Aks
targeted mutation 1, Alar Karis
MGI:3608888
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ric8atm1Aks/Ric8atm1Aks B6.129P2-Ric8atm1Aks MGI:3700168
ht2
 		Ric8atm1Aks/Ric8a+ B6.129P2-Ric8atm1Aks MGI:3700169
cn3
 		Ric8atm1Aks/Ric8atm1.1Zhua
Tg(Atoh1-cre/Esr1*)14Fsh/0 		involves: 129P2/OlaHsd * FVB/N MGI:5467517


Genotype
MGI:3700168
hm1
Allelic
Composition		 Ric8atm1Aks/Ric8atm1Aks
Genetic
Background		 B6.129P2-Ric8atm1Aks
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ric8atm1Aks mutation (0 available); any Ric8a mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3700169
ht2
Allelic
Composition		 Ric8atm1Aks/Ric8a+
Genetic
Background		 B6.129P2-Ric8atm1Aks
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ric8atm1Aks mutation (0 available); any Ric8a mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal spatial learning ( J:115754 )
• performance in the Morris water maze is impaired, with heterozygotes exhibiting a delay in finding the hidden platform during reversal testing
increased anxiety-related response ( J:115754 )
• mice exhibit increased anxiety in light-dark compartment test where they significantly avoid the light compartment




Genotype
MGI:5467517
cn3
Allelic
Composition		 Ric8atm1Aks/Ric8atm1.1Zhua
Tg(Atoh1-cre/Esr1*)14Fsh/0
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ric8atm1.1Zhua mutation (0 available); any Ric8a mutation (29 available)
Ric8atm1Aks mutation (0 available); any Ric8a mutation (29 available)
Tg(Atoh1-cre/Esr1*)14Fsh mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:191222 )
N
• granule cell precursors are normal in tamoxifen-treated mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
08/02/2024
MGI 6.24 		The Jackson Laboratory