Phenotypes associated with this allele

• Allele Symbol: Cpb2^tm1Jcmm
• Allele Name: targeted mutation 1, J C M Meijers
• Allele ID: MGI:3608921
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cpb2^tm1Jcmm/Cpb2^tm1Jcmm	involves: 129P2/OlaHsd * C57BL/6J	MGI:3609163

Genotype
MGI:3609163

hm1

• Allelic Composition: Cpb2^tm1Jcmm/Cpb2^tm1Jcmm
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:102729 )

• mortality is increased after colonic anastomoses compared to wild-type

neoplasm

neoplasm ( J:102166 )

N • no differences in experimentally or spontaneously induced formation and growth of primary and metastasized tumors compared with wild-type

homeostasis/metabolism

abnormal thrombolysis ( J:102729 )

• plasma clots are lysed rapidly compared to wild-type in which clots are protected from lysis

abnormal wound healing ( J:102729 )

delayed wound healing ( J:102729 )

• 38% and 63% of wounds on day 4 and 7, respectively, exhibited complete re-epithelialization compared to 89% and 100% in wild-type, however all completed re-epithelialization by day 15

impaired wound healing ( J:102729 )

• aberrant epithelial cell migration such that keratinocytes migrate down into the dermal layer rather than towards the other edge of the wound, resulting in prolonged wound healing

• form sinuses and keratinocyte inclusions in skin wounds which are not observed in wild-type

• healing of colonic anastomoses is impaired as indicated by decreased strength of tissue at the site of the suture, worse postoperative recovery and bleeding complications in 3 of 14 mice