Phenotypes associated with this allele

• Allele Symbol: Men1^tm1Mmey
• Allele Name: targeted mutation 1, Matthew Meyerson
• Allele ID: MGI:3608952
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Men1^tm1Mmey/Men1^tm1Mmey	involves: 129S6/SvEvTac * FVB/N	MGI:3610555
ht2	Men1^tm1Mmey/Men1^+	involves: 129S6/SvEvTac * FVB/N	MGI:3610556

Genotype
MGI:3610555

hm1

• Allelic Composition: Men1^tm1Mmey/Men1^tm1Mmey
• Genetic Background: involves: 129S6/SvEvTac * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:88588 )

• homozygous mutant embryo do not develop past day 11.5-12.5 postcoitum

Genotype
MGI:3610556

ht2

• Allelic Composition: Men1^tm1Mmey/Men1⁺
• Genetic Background: involves: 129S6/SvEvTac * FVB/N

endocrine/exocrine glands

increased pancreatic beta cell number ( J:102494 )

• by 7 months of age, heterozygous mice have hyperplastic and enlarged pancreatic islets

• an increase in numbers of insulin + beta cells in mutant

homeostasis/metabolism

hypoglycemia ( J:102494 )

• by 6-7 months of age, heterozygous mice had mild but significant hypoglycemia during random feeding and after overnight fasting