Phenotypes associated with this allele

• Allele Symbol: Rhbg^tm1Rc
• Allele Name: targeted mutation 1, Regine Chambrey
• Allele ID: MGI:3608962
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rhbg^tm1Rc/Rhbg^tm1Rc	involves: 129P2/Ola * C57BL/6	MGI:3610454

Genotype
MGI:3610454

hm1

• Allelic Composition: Rhbg^tm1Rc/Rhbg^tm1Rc
• Genetic Background: involves: 129P2/Ola * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:102456 )

• mutant mice did not exhibit encephalopathy and survived well

• mutant mice did not exhibit hallmark of distal tubular acidosis

• mutant mice did not have hyperammonemia or disturbed hepatic NH3 metabolism

• mutant mice adapted to a chronic acido-loading challenge as well as control

• transepithelial NH3 diffusive permeability, or NH3 and NH4+ entry across the basolateral membrane of collecting duct from mutant and wild-type mice was identical