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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Aqp7tm1.1Suc
targeted mutation 1.1, Shinichi Uchida
MGI:3608967
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Aqp7tm1.1Suc/Aqp7tm1.1Suc involves: 129S2/SvPas * C57BL/6J MGI:3609475
cx2
 		Aqp1tm1Ask/Aqp1tm1Ask
Aqp7tm1.1Suc/Aqp7tm1.1Suc 		involves: 129S2/SvPas * C57BL/6J MGI:3609478


Genotype
MGI:3609475
hm1
Allelic
Composition		 Aqp7tm1.1Suc/Aqp7tm1.1Suc
Genetic
Background		 involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aqp7tm1.1Suc mutation (0 available); any Aqp7 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
increased urine glucose level ( J:102454 )
• higher urine glucose levels than in wild-type, however plasma and urine urea levels are normal
abnormal kidney physiology ( J:102454 )
• water permeability of the brush-border membrane vesicles from the outer medulla is slightly but significantly lower than that of wild-type, however do not exhibit a urinary concentrating defect

homeostasis/metabolism
increased urine glucose level ( J:102454 )
• higher urine glucose levels than in wild-type, however plasma and urine urea levels are normal

reproductive system
reproductive system phenotype ( J:129600 )
N
• contrary to expectation, 15-wk-old mutant males are fully fertile, with no significant differences in offspring number, testicular weight- and epididymal weight-to-body weight ratios, daily sperm production, sperm motility, sperm morphology and morphometry or in vitro fertilization capacity relative to wild-type males




Genotype
MGI:3609478
cx2
Allelic
Composition		 Aqp1tm1Ask/Aqp1tm1Ask
Aqp7tm1.1Suc/Aqp7tm1.1Suc
Genetic
Background		 involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aqp1tm1Ask mutation (0 available); any Aqp1 mutation (23 available)
Aqp7tm1.1Suc mutation (0 available); any Aqp7 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
increased urine glucose level ( J:102454 )
• higher than in wild-type and single homozygous Aqp1 mice, however plasma and urine urea levels are normal
decreased urine osmolality ( J:102454 )
• before and after a 36 hour water-depriavation period, urine osmolarity is reduced compared to homozygous Aqp1 mice
abnormal kidney physiology ( J:102454 )
• water permeability of the brush-border membrane vesicles from the outer medulla is lower than that of single homozygous Aqp1 mice and wild-type
polyuria ( J:102454 )
• under normal conditions, urine volume increases significantly compared to homozygous Aqp1 mice

growth/size/body
weight loss ( J:102454 )
• observe a significantly greater weight loss after dehydration than in homozygous Aqp1 mice

homeostasis/metabolism
increased urine glucose level ( J:102454 )
• higher than in wild-type and single homozygous Aqp1 mice, however plasma and urine urea levels are normal
decreased urine osmolality ( J:102454 )
• before and after a 36 hour water-depriavation period, urine osmolarity is reduced compared to homozygous Aqp1 mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory