Phenotypes associated with this allele

• Allele Symbol: Psen1^tm1Dgf
• Allele Name: targeted mutation 1, Dorothy G Flood
• Allele ID: MGI:3608968
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Psen1^tm1Dgf/Psen1^tm1Dgf	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:4413474
cx2	Psen1^tm1Dgf/Psen1^tm1Dgf Tg(APPSWE)2576Kha/?	involves: 129 * C57BL/6 * CD-1 * SJL	MGI:3611211
cx3	App^tm1.1Cep/App^tm1.1Cep Psen1^tm1Dgf/Psen1^tm1Dgf	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3611210
cx4	Psen1^tm1Dgf/Psen1^+ Tg(APPSWE)2576Kha/0	involves: 129S1/Sv * 129X1/SvJ * CD-1 * C57BL/6 * SJL	MGI:2652383

Genotype
MGI:4413474

hm1

• Allelic Composition: Psen1^tm1Dgf/Psen1^tm1Dgf
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:66147 )

N • basal level of cortical neuron apoptosis in response to three different apoptogenic agents is similar to controls

Genotype
MGI:3611211

cx2

• Allelic Composition: Psen1^tm1Dgf/Psen1^tm1Dgf; Tg(APPSWE)2576Kha/?
• Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL

nervous system

amyloid beta deposits ( J:102425 )

• accelerated onset of amyloid deposition in a gene-dosage dependent manner

• amyloid-beta deposition was widely distributed throughout the brain and spinal cord

homeostasis/metabolism

amyloid beta deposits ( J:102425 )

• accelerated onset of amyloid deposition in a gene-dosage dependent manner

• amyloid-beta deposition was widely distributed throughout the brain and spinal cord

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:102425

Genotype
MGI:3611210

cx3

• Allelic Composition: App^tm1.1Cep/App^tm1.1Cep; Psen1^tm1Dgf/Psen1^tm1Dgf
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

nervous system

amyloid beta deposits ( J:66147 , J:102425 )

• mutants exhibit enhanced amyloidogenic APP processing in cortical neurons and accelerated onset of amyloid deposition (J:66147)

• amyloid-beta deposition beginning at 6 months of age (J:102425)

• deposition increased linearly over time (J:102425)

homeostasis/metabolism

amyloid beta deposits ( J:66147 , J:102425 )

• mutants exhibit enhanced amyloidogenic APP processing in cortical neurons and accelerated onset of amyloid deposition (J:66147)

• amyloid-beta deposition beginning at 6 months of age (J:102425)

• deposition increased linearly over time (J:102425)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:102425

Genotype
MGI:2652383

cx4

• Allelic Composition: Psen1^tm1Dgf/Psen1⁺; Tg(APPSWE)2576Kha/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 * C57BL/6 * SJL

nervous system

amyloid beta deposits ( J:66147 )

• accelerated onset of amyloid plaque deposition and increased amyloidogenic processing of APP compared to single Tg(APPSWE)2576Kha mice

gliosis ( J:66147 )

• mutants exhibit enhanced reactive gliosis compared to single Tg(APPSWE)2576Kha mice

homeostasis/metabolism

amyloid beta deposits ( J:66147 )

• accelerated onset of amyloid plaque deposition and increased amyloidogenic processing of APP compared to single Tg(APPSWE)2576Kha mice