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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ightm3Tim
targeted mutation 3, Tim Manser
MGI:3609136
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Ightm3Tim/Igh+ involves: 129 * C57BL/6 MGI:3610402
cx2
 		Igh-Jtm1Dhu/Ightm3Tim involves: 129 * C57BL/6 MGI:3610405
cx3
 		Ighmtm1Cgn/Ightm3Tim involves: 129 * C57BL/6 MGI:3610407


Genotype
MGI:3610402
ht1
Allelic
Composition		 Ightm3Tim/Igh+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm3Tim mutation (0 available); any Igh mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal B cell differentiation ( J:102308 )
• preferentially promoted development to marginal zone B cell
• inefficiently drives bone marrow B lymphopoiesis and follicular B cell development
abnormal bone marrow cell number ( J:102308 )
• B cell compartment in mutant bone marrow was heterogeneous
abnormal spleen B cell follicle morphology ( J:102308 )
• B cell compartment in mutant spleen was heterogeneous

immune system
abnormal B cell differentiation ( J:102308 )
• preferentially promoted development to marginal zone B cell
• inefficiently drives bone marrow B lymphopoiesis and follicular B cell development
abnormal spleen B cell follicle morphology ( J:102308 )
• B cell compartment in mutant spleen was heterogeneous




Genotype
MGI:3610405
cx2
Allelic
Composition		 Igh-Jtm1Dhu/Ightm3Tim
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Dhu mutation (1 available); any Igh-J mutation (13 available)
Ightm3Tim mutation (0 available); any Igh mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal B cell differentiation ( J:102308 )
• preferentially promoted development to marginal zone B cell
• inefficiently drives bone marrow B lymphopoiesis and follicular B cell development
decreased B cell number ( J:102308 )
• B cell in mutants are reduced in the spleen, bone marrow and LNs

immune system
abnormal B cell differentiation ( J:102308 )
• preferentially promoted development to marginal zone B cell
• inefficiently drives bone marrow B lymphopoiesis and follicular B cell development
decreased B cell number ( J:102308 )
• B cell in mutants are reduced in the spleen, bone marrow and LNs




Genotype
MGI:3610407
cx3
Allelic
Composition		 Ighmtm1Cgn/Ightm3Tim
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighmtm1Cgn mutation (17 available); any Ighm mutation (56 available)
Ightm3Tim mutation (0 available); any Igh mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal B cell differentiation ( J:102308 )
• preferentially promoted development to marginal zone B cell
• inefficiently drives bone marrow B lymphopoiesis and follicular B cell development
decreased B cell number ( J:102308 )
• B cell in mutants are reduced in the spleen, bone marrow and LNs

immune system
abnormal B cell differentiation ( J:102308 )
• preferentially promoted development to marginal zone B cell
• inefficiently drives bone marrow B lymphopoiesis and follicular B cell development
decreased B cell number ( J:102308 )
• B cell in mutants are reduced in the spleen, bone marrow and LNs




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory