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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ightm3.1Tim
targeted mutation 3.1, Tim Manser
MGI:3609137
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Ightm3.1Tim/Igh+ involves: 129 * C57BL/6 MGI:3610404


Genotype
MGI:3610404
ht1
Allelic
Composition		 Ightm3.1Tim/Igh+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm3.1Tim mutation (0 available); any Igh mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal B cell differentiation ( J:102308 )
• preferentially promoted development to marginal zone B cell
• inefficiently drives bone marrow B lymphopoiesis and follicular B cell development
abnormal bone marrow cell number ( J:102308 )
• B cell compartment in mutant bone marrow was heterogeneous
abnormal spleen B cell follicle morphology ( J:102308 )
• B cell compartment in mutant spleen was heterogeneous

immune system
abnormal B cell differentiation ( J:102308 )
• preferentially promoted development to marginal zone B cell
• inefficiently drives bone marrow B lymphopoiesis and follicular B cell development
abnormal spleen B cell follicle morphology ( J:102308 )
• B cell compartment in mutant spleen was heterogeneous




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory