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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mertktm1Lex
targeted mutation 1, Lexicon Genetics
MGI:3609164
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mertktm1Lex/Mertktm1Lex involves: 129S5/SvEvBrd * C57BL/6 MGI:3609493


Genotype
MGI:3609493
hm1
Allelic
Composition		 Mertktm1Lex/Mertktm1Lex
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mertktm1Lex mutation (1 available); any Mertk mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased platelet aggregation ( J:102333 )
• platelet aggregation response was decreased in response to certain platelet agonists (low concentrations of collagen, U46619, and PAR4 thrombin receptor agonist peptide) in vitro, however response to ADP was not different

homeostasis/metabolism
decreased platelet aggregation ( J:102333 )
• platelet aggregation response was decreased in response to certain platelet agonists (low concentrations of collagen, U46619, and PAR4 thrombin receptor agonist peptide) in vitro, however response to ADP was not different
decreased susceptibility to induced thrombosis ( J:102333 )
• mice exhibit protection from collagen/epinephrine-induced pulmonary thromboembolism and ferric chloride-induced thrombosis




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory