Analysis Tools
behavior/neurological
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• mice urinate throughout the cages, even on their nest
• reductions in cage management behaviors indicate reduced social responsibility
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• in a shuttle box test, mice show reduced latency to enter the compartment and an increased frequency of entries in a recall trial, indicating that mice do not learn to fear the shock lesson and exhibit risk-ignoring behaviors
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• in a drowning rescue test, mice spend less time near the container containing a struggling-against-drowning mouse and have fewer contacting movement traces, indicating reduced empathic behavior
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• in the open field, mice exhibit a greater total distance traveled indicating an increase in locomotor response to environmental novelty, a phenotype associated with impulsivity
• however, time in central versus periphery is not different
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• mice exhibit bare patches in their coats from severe bite wounds, suggesting mice are more aggressive
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• in the resident-intruder paradigm test, mice show a shorter latency to the first biting attack, a higher attack frequency and longer total duration of attack episodes
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• mice interact more with the novel object that is introduced in the home cage compared to wild-type mice, indicating increased impulsivity
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• in a three-chamber social behavior test, mice show no preference to stay with the stranger mice as seen in controls, indicating that mice have social preference injury
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• in the open field test, exposure to novel object, and novelty-suppressed feeding, mice show increased impulsive behavior, showing a greater total distance traveled in the open field, interacting more with the novel object, and having shorter eating latencies, respectively
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• mice show little or no nesting behavior
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nervous system
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• the amplitude of miniature excitatory postsynaptic currents (mEPSCs) is reduced in layer II/III pyramidal neurons of the medial prefrontal cortex
• however, mEPSC frequency is not different
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| antisocial personality disorder | DOID:10939 | J:322011 | ||
