Analysis Tools
immune system
|
• following culture in the presence of either LPS, LPS and IFNG, or LPS, IFNG, and 15dPGJ2 fewer than 15% of macrophages undergo apoptosis compared to from 20% to 50% of wild-type cells
|
|
• T cell proliferation in response to anti-CD3E antibody or anti-TCRalphabeta antibody is reduced to 80% of control
|
|
• macrophages produce less NO following LPS stimulation and less NO, TNF, IL1B, and PGE2 following LPS and IFNG stimulation
|
|
• serum levels of IL1B are significantly reduced
|
|
• serum levels of TNFA are significantly reduced
|
|
• survival time is decreased following exposure to either Gram-negative or Gram-positive bacteria
|
reproductive system
 |
• high levels of Gram-negative bacteria are detected in the uterine fluid
|
|
|
• about 30% of females have distended fluid-filled uteri
|
|
|
• only 1 in 4 females produce a litter and second litters are even less common
|
growth/size/body
|
• 10-15% smaller than control littermates
|
adipose tissue
|
• homozygotes do not develop increased adipose tissue with age to the same extent as in wild-type mice
|
cardiovascular system
|
• in the absence of preconditioning ischemia-induced myocardial infarct size is similar to controls; however, following ischemia preconditioning (4 bouts of 4 min ischemia and 6 min reperfusion) no decrease in ischemia-induced myocardial infarct size is seen unlike in controls
• ischemia preconditioning in both controls and homozygotes does improve contractile recovery following ischemia
|
hematopoietic system
|
• following culture in the presence of either LPS, LPS and IFNG, or LPS, IFNG, and 15dPGJ2 fewer than 15% of macrophages undergo apoptosis compared to from 20% to 50% of wild-type cells
|
|
• T cell proliferation in response to anti-CD3E antibody or anti-TCRalphabeta antibody is reduced to 80% of control
|
|
• macrophages produce less NO following LPS stimulation and less NO, TNF, IL1B, and PGE2 following LPS and IFNG stimulation
|
homeostasis/metabolism
|
• in the absence of preconditioning ischemia-induced myocardial infarct size is similar to controls; however, following ischemia preconditioning (4 bouts of 4 min ischemia and 6 min reperfusion) no decrease in ischemia-induced myocardial infarct size is seen unlike in controls
• ischemia preconditioning in both controls and homozygotes does improve contractile recovery following ischemia
|
|
• macrophages produce less NO following LPS stimulation and less NO, TNF, IL1B, and PGE2 following LPS and IFNG stimulation
|
|
• serum levels of IL1B are significantly reduced
|
|
• serum levels of TNFA are significantly reduced
|
cellular
|
• following culture in the presence of either LPS, LPS and IFNG, or LPS, IFNG, and 15dPGJ2 fewer than 15% of macrophages undergo apoptosis compared to from 20% to 50% of wild-type cells
|
|
• T cell proliferation in response to anti-CD3E antibody or anti-TCRalphabeta antibody is reduced to 80% of control
|
