Phenotypes associated with this allele

• Allele Symbol: Fabp3^tm1Jshr
• Allele Name: targeted mutation 1, Jane Shearer
• Allele ID: MGI:3609428
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Fabp3^tm1Jshr/Fabp3^+	B6.129-Fabp3^tm1Jshr	MGI:3621821

Genotype
MGI:3621821

ht1

• Allelic Composition: Fabp3^tm1Jshr/Fabp3⁺
• Genetic Background: B6.129-Fabp3^tm1Jshr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating glucose level ( J:102858 )

• on a high fat diet heterozygotes do no develop hyperglycemia unlike wild-type mice; however, both heterozygotes and wild-type mice develop hyperinsulinemia on a high fat diet

• no difference in glucose level is seen when mice are fed a chow diet

increased insulin sensitivity ( J:102858 )

• during insulin infusion heterozygotes on a high fat diet require more glucose to maintain glycemia (decreased insulin resistance) compared to wild-type mice also fed a high fat diet

• no suppression of insulin stimulated muscle glucose metabolism or clearance is seen in heterozygotes on a high fat diet unlike wild-type mice

• no difference in insulin sensitivity is seen when mice are fed a chow diet