Analysis Tools|
Allele Symbol Allele Name Allele ID |
Admtm1Tfjt targeted mutation 1, Toshiro Fujita MGI:3609557 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in severe cases fibrinoid necrosis is seen in the perivascular area of the coronary artery in heterozygous mice given angiotensin II and fed a high salt diet
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• inflammation of the perivascular area of the coronary artery is more severe in heterozygous mice given angiotensin II and fed a high salt diet compared to similarly treated wild-type mice
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• elevated urinary excretion of 8-hydroxydeoxyguanosine and isoprostane, elevated expression of Ncf2 and Cybb, and increased 3-nitrotyrosine staining all indicate elevated oxidative stress in the hearts of heterozygous mice given angiotensin II and fed a high salt diet compared to similarly treated wild-type mice
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• inflammation of the perivascular area of the coronary artery is more severe in heterozygous mice given angiotensin II and fed a high salt diet compared to similarly treated wild-type mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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