All Phenotypes Sytl4<tm1Tiz> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sytl4^tm1Tiz
targeted mutation 1, Tetsuro Izumi
MGI:3609563

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sytl4^tm1Tiz/Sytl4^tm1Tiz	involves: 129P2/OlaHsd * C3H/He	MGI:3612159
cx2	Sytl1^tm1Tiz/Sytl1^tm1Tiz Sytl4^tm1Tiz/Sytl4^tm1Tiz	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NTac	MGI:5509461
ot3	Sytl4^tm1Tiz/Y	involves: 129P2/OlaHsd	MGI:3834157

Allelic Composition	Sytl4^tm1Tiz/Sytl4^tm1Tiz
Genetic Background	involves: 129P2/OlaHsd * C3H/He

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sytl4^tm1Tiz mutation (1 available); any Sytl4 mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:102610 )

• a reduction of approximately 10% at all ages examined

homeostasis/metabolism

increased insulin secretion ( J:102610 )

• insulin secretion in response to 16.7 mM glucose was significantly enhanced in both the first and second phases by approximately 200% of the control level

decreased circulating glucose level ( J:102610 )

• the blood glucose levels examined in fasting mice or after a glucose load were significantly lower in mutant mice

endocrine/exocrine glands

abnormal pancreatic beta cell morphology ( J:102610 )

• the ultrastructure of the mutant beta cells showed a deficit in insulin-granule docking at the plasma membrane

• the number of docked granules was significantly reduced

• the granule number per cell section, the beta cell size, and the average granule density were unchanged

increased insulin secretion ( J:102610 )

• insulin secretion in response to 16.7 mM glucose was significantly enhanced in both the first and second phases by approximately 200% of the control level

Allelic Composition	Sytl1^tm1Tiz/Sytl1^tm1Tiz Sytl4^tm1Tiz/Sytl4^tm1Tiz
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sytl1^tm1Tiz mutation (1 available); any Sytl1 mutation (27 available)
Sytl4^tm1Tiz mutation (1 available); any Sytl4 mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal pancreatic beta cell morphology ( J:200233 )

• beta cells lack docked granules whose lining membrane is directly attached to the plasma membrane and have fewer granules with centers within 300 nm of the plasma membrane compared with wild-type cells

decreased insulin secretion ( J:200233 )

• glucose-stimulated

homeostasis/metabolism

decreased insulin secretion ( J:200233 )

• glucose-stimulated

Allelic Composition	Sytl4^tm1Tiz/Y
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sytl4^tm1Tiz mutation (1 available); any Sytl4 mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal corticotroph morphology ( J:145238 )

• the docking granules whose limiting membrane directly attaches to the plasma membrane are lacking unlike in wild-type mice

hypersecretion of adrenocorticotropin ( J:145238 )

• evoked

nervous system

abnormal corticotroph morphology ( J:145238 )

• the docking granules whose limiting membrane directly attaches to the plasma membrane are lacking unlike in wild-type mice

hypersecretion of adrenocorticotropin ( J:145238 )

• evoked

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