Phenotypes associated with this allele

• Allele Symbol: Slc8a1^tm2Kdp
• Allele Name: targeted mutation 2, Kenneth D Philipson
• Allele ID: MGI:3609617
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc8a1^tm2Kdp/Slc8a1^tm2Kdp	involves: 129S4/SvJae * Black Swiss	MGI:3611571

Genotype
MGI:3611571

hm1

• Allelic Composition: Slc8a1^tm2Kdp/Slc8a1^tm2Kdp
• Genetic Background: involves: 129S4/SvJae * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:103484 )

• mutant mice are embryonic lethal at 11.0 days postcoitum

cardiovascular system

abnormal fetal cardiomyocyte morphology ( J:102710 )

• sarcoplasmic reticular membranes are diminished in mutant embryonic heart tubes at day 9.5 postcoitum

abnormal cardiovascular system physiology ( J:102710 , J:103484 )

• mutant embryonic heart tubes at day 9.5 postcoitum display normal calcium transients under basal conditions, but are unable to maintain homeostasis when calcium fluxes are increased by various interventions (J:102710)

• mutant embryonic heart tubes at day 9.5 postcoitum display spontaneous calcium transients and contractile activity (J:103484)

• removal of extracellular sodium does not alter the calcium transients (J:103484)

• ouabain has no effect on mutant heart tube (J:103484)