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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Steap3tm1.1Mdf
targeted mutation 1.1, Mark D Fleming
MGI:3609928
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Steap3tm1.1Mdf/Steap3tm1.1Mdf involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * CBA/J MGI:3609931
cx2
 		Del(1)1Brk/Steap3tm1.1Mdf involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * CBA/J MGI:3609989


Genotype
MGI:3609931
hm1
Allelic
Composition		 Steap3tm1.1Mdf/Steap3tm1.1Mdf
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Steap3tm1.1Mdf mutation (1 available); any Steap3 mutation (63 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal iron homeostasis ( J:103440 )
• the transferrin-mediated iron uptake rate of reticulocyte-rich RBCs from 8 week old homozygous mutant mice is only about 30% that of such cells from wild-type mice
• upon reincubation with medium containing excess apo-transferrin, iron-laden erythrocytes from 8 week old homozygous mutant mice lose a significant proportion (17.8 +/- 3.3%) of the iron previously taken up by the cells
• at 8 weeks of age, the erythrocyte zinc-to-iron protoporphoryn IX ratio of homozygous mutant mice is approximately 3.5-fold that of wild-type mice
increased liver iron level ( J:103440 )
• the liver iron content of homozygous mutant mice is approximately 3-fold higher than that of wild-type mice

hematopoietic system
decreased hematocrit ( J:103440 )
• the hematocrit of 8 week old mice homozygous for the targeted mutation is about 75% that of wild-type mice
decreased hemoglobin content ( J:103440 )
• blood of 8 week old mice homozygous for the targeted mutation has a hemoglobin (g/dl) content about 64% that of blood from wild-type mice
decreased mean corpuscular hemoglobin ( J:103440 )
• red blood cells of 8 week old homozygous mutant mice contain only about 39% as much hemoglobin (pg) as RBCs of wild-type mice
decreased mean corpuscular hemoglobin concentration ( J:103440 )
• the hemoglobin concentration in red blood cells from 8 week old homozygous mutant mice is about 82% that of wild-type mice
decreased mean corpuscular volume ( J:103440 )
• 8 week old homozygous mutant mice have a mean RBC volume less than half that of wild-type mice
anisopoikilocytosis ( J:103440 )
• red blood cells of homozygous mutants vary in shape and size
thrombocytosis ( J:103440 )
• the platelet count of 8 week old homozygous mutant mice is 4 times that of wild-type mice
abnormal reticulocyte morphology ( J:103440 )
• reticulocytes of 8 week old homozygous mutant mice contain only half the cellular hemoglobin of those from wild-type mice
reticulocytosis ( J:103440 )
• in blood of 8 week old homozygous mutant mice, both the absolute number and the proportion of reticulocytes are significantly elevated over those in blood of mice with at least one wild-type allele

liver/biliary system
increased liver iron level ( J:103440 )
• the liver iron content of homozygous mutant mice is approximately 3-fold higher than that of wild-type mice




Genotype
MGI:3609989
cx2
Allelic
Composition		 Del(1)1Brk/Steap3tm1.1Mdf
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(1)1Brk mutation (1 available); any Del(1)1Brk mutation (1 available)
Steap3tm1.1Mdf mutation (1 available); any Steap3 mutation (63 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased hematocrit ( J:103440 )
• the hematocrit of 8 week old mice bearing the deletion in trans with the targeted allele is about 75% that of wild-type mice
decreased hemoglobin content ( J:103440 )
• blood of 8 week old complex heterozygous mice has a hemoglobin (g/dl) content about 65% that of blood from wild-type mice
decreased mean corpuscular hemoglobin ( J:103440 )
• red blood cells of 8 week old complex heterozygous mice contain only about 38% as much hemoglobin (pg) as RBCs of wild-type mice
decreased mean corpuscular hemoglobin concentration ( J:103440 )
• the hemoglobin concentration in red blood cells from 8 week old complex homozygotes is about 83% that of wild-type mice
decreased mean corpuscular volume ( J:103440 )
• 8 week old complex heterozygotes have a mean RBC volume approximately 45% that of wild-type mice
anisopoikilocytosis ( J:103440 )
• red blood cells of complex heterozygotes vary in shape and size
thrombocytosis ( J:103440 )
• the platelet count of 8 week old complex heterozygous mice is about 4.27 times that of wild-type mice
abnormal reticulocyte morphology ( J:103440 )
• reticulocytes of 8 week old complex heterozygous mice contain approximately half the cellular hemoglobin of those from wild-type mice
reticulocytosis ( J:103440 )
• in blood of 8 week old complex heterozygotes, both the absolute number and the proportion of reticulocytes are significantly elevated over those in blood of mice with at least one wild-type allele

homeostasis/metabolism
abnormal iron homeostasis ( J:103440 )
• the erythrocyte zinc-to-iron protoporphyrin IX ratio of 8 week old complex heterozygous mice is approximately 4.7-fold that of wild-type mice
increased liver iron level ( J:103440 )
• the liver iron content of complex heterozygotes is approximately 3-fold that of wild-type mice

liver/biliary system
increased liver iron level ( J:103440 )
• the liver iron content of complex heterozygotes is approximately 3-fold that of wild-type mice




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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory