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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nt5etm1Jsc
targeted mutation 1, Jurgen Schrader
MGI:3609975
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nt5etm1Jsc/Nt5etm1Jsc involves: 129S1/Sv * 129X1/SvJ * NMRI MGI:3612992


Genotype
MGI:3612992
hm1
Allelic
Composition		 Nt5etm1Jsc/Nt5etm1Jsc
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nt5etm1Jsc mutation (0 available); any Nt5e mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased coronary flow rate ( J:102299 )
• basal coronary flow measured in the isolated perfused heart was significantly lower

homeostasis/metabolism
abnormal platelet physiology ( J:102299 )
• platelet cAMP but not cGMP was significantly reduced
increased susceptibility to induced thrombosis ( J:102299 )
• time to carotid artery occlusion induced by FeCl3 was significantly reduced
decreased bleeding time ( J:102299 )
• bleeding time after tail tip resection tended to be shorter but did not reach the level of significance

hematopoietic system
abnormal platelet physiology ( J:102299 )
• platelet cAMP but not cGMP was significantly reduced




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory